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https://doi.org/10.3389/fmicb.2014.00586
Title: | Novel approaches to identify protective malaria vaccine candidates | Authors: | Chia, W.N Goh, Y.S Rénia, L |
Keywords: | antibody antigen antiserum apical membrane antigen 1 bacterium lysate circumsporozoite protein erythrocyte antigen gamma interferon genomic DNA immunoglobulin G malaria vaccine PfRh5 protein recombinant protein ring erythrocyte surface antigen unclassified drug CD8+ T lymphocyte cellular immunity disease course gene sequence genetic screening host parasite interaction human immune response malaria malaria control matrix assisted laser desorption ionization time of flight mass spectrometry nonhuman parasite clearance Plasmodium falciparum protein microarray Review sporozoite vaccination Plasmodium falciparum |
Issue Date: | 2014 | Citation: | Chia, W.N, Goh, Y.S, Rénia, L (2014). Novel approaches to identify protective malaria vaccine candidates. Frontiers in Microbiology 5 (NOV) : 586. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2014.00586 | Rights: | Attribution 4.0 International | Abstract: | Efforts to develop vaccines against malaria have been the focus of substantial research activities for decades. Several categories of candidate vaccines are currently being developed for protection against malaria, based on antigens corresponding to the pre-erythrocytic, blood stage, or sexual stages of the parasite. Long lasting sterile protection from Plasmodium falciparum sporozoite challenge has been observed in human following vaccination with whole parasite formulations, clearly demonstrating that a protective immune response targeting predominantly the pre-erythrocytic stages can develop against malaria. However, most of vaccine candidates currently being investigated, which are mostly subunits vaccines, have not been able to induce substantial (>50%) protection thus far. This is due to the fact that the antigens responsible for protection against the different parasite stages are still yet to be known and relevant correlates of protection have remained elusive. For a vaccine to be developed in a timely manner, novel approaches are required. In this article, we review the novel approaches that have been developed to identify the antigens for the development of an effective malaria vaccine. © 2014 Chia, Goh and Rénia. | Source Title: | Frontiers in Microbiology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181769 | ISSN: | 1664302X | DOI: | 10.3389/fmicb.2014.00586 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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