Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2014.00586
Title: Novel approaches to identify protective malaria vaccine candidates
Authors: Chia, W.N 
Goh, Y.S
Rénia, L 
Keywords: antibody
antigen
antiserum
apical membrane antigen 1
bacterium lysate
circumsporozoite protein
erythrocyte antigen
gamma interferon
genomic DNA
immunoglobulin G
malaria vaccine
PfRh5 protein
recombinant protein
ring erythrocyte surface antigen
unclassified drug
CD8+ T lymphocyte
cellular immunity
disease course
gene sequence
genetic screening
host parasite interaction
human
immune response
malaria
malaria control
matrix assisted laser desorption ionization time of flight mass spectrometry
nonhuman
parasite clearance
Plasmodium falciparum
protein microarray
Review
sporozoite
vaccination
Plasmodium falciparum
Issue Date: 2014
Citation: Chia, W.N, Goh, Y.S, Rénia, L (2014). Novel approaches to identify protective malaria vaccine candidates. Frontiers in Microbiology 5 (NOV) : 586. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2014.00586
Rights: Attribution 4.0 International
Abstract: Efforts to develop vaccines against malaria have been the focus of substantial research activities for decades. Several categories of candidate vaccines are currently being developed for protection against malaria, based on antigens corresponding to the pre-erythrocytic, blood stage, or sexual stages of the parasite. Long lasting sterile protection from Plasmodium falciparum sporozoite challenge has been observed in human following vaccination with whole parasite formulations, clearly demonstrating that a protective immune response targeting predominantly the pre-erythrocytic stages can develop against malaria. However, most of vaccine candidates currently being investigated, which are mostly subunits vaccines, have not been able to induce substantial (>50%) protection thus far. This is due to the fact that the antigens responsible for protection against the different parasite stages are still yet to be known and relevant correlates of protection have remained elusive. For a vaccine to be developed in a timely manner, novel approaches are required. In this article, we review the novel approaches that have been developed to identify the antigens for the development of an effective malaria vaccine. © 2014 Chia, Goh and Rénia.
Source Title: Frontiers in Microbiology
URI: https://scholarbank.nus.edu.sg/handle/10635/181769
ISSN: 1664302X
DOI: 10.3389/fmicb.2014.00586
Rights: Attribution 4.0 International
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