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https://doi.org/10.1186/1475-925X-10-52
Title: | Towards patient-specific cardiovascular modeling system using the immersed boundary technique | Authors: | Tay, W.-B Tseng, Y.-H Lin, L.-Y Tseng, W.-Y |
Keywords: | Cardiovascular models Immersed boundary technique Patient specific Cardiac health CFD models Clinical data Comprehensive analysis Early diagnosis Elastic boundary Experimental data Flow dynamics Flow features Heart model Hybrid computational Immersed boundary methods Immersed boundary technique Left ventricles Modeling systems Pulmonary veins Reservoir pressures Time-resolved Diagnosis Flow rate Heart Hybrid systems Magnetic resonance imaging Resonance Three dimensional Turbulent flow Computational fluid dynamics adult article biological model blood flow velocity cardiovascular system comparative study computer assisted diagnosis computer simulation evaluation female heart disease heart ventricle hemodynamics human hydrodynamics kinetics metabolism methodology nuclear magnetic resonance imaging physiology pressure Adult Blood Flow Velocity Cardiovascular System Computer Simulation Female Heart Diseases Heart Ventricles Hemodynamics Humans Hydrodynamics Image Interpretation, Computer-Assisted Kinetics Magnetic Resonance Imaging Models, Cardiovascular Pressure |
Issue Date: | 2011 | Citation: | Tay, W.-B, Tseng, Y.-H, Lin, L.-Y, Tseng, W.-Y (2011). Towards patient-specific cardiovascular modeling system using the immersed boundary technique. BioMedical Engineering Online 10 (1) : 52. ScholarBank@NUS Repository. https://doi.org/10.1186/1475-925X-10-52 | Rights: | Attribution 4.0 International | Abstract: | Background: Previous research shows that the flow dynamics in the left ventricle (LV) reveal important information about cardiac health. This information can be used in early diagnosis of patients with potential heart problems. The current study introduces a patient-specific cardiovascular-modelling system (CMS) which simulates the flow dynamics in the LV to facilitate physicians in early diagnosis of patients before heart failure. Methods: The proposed system will identify possible disease conditions and facilitates early diagnosis through hybrid computational fluid dynamics (CFD) simulation and time-resolved magnetic resonance imaging (4-D MRI). The simulation is based on the 3-D heart model, which can simultaneously compute fluid and elastic boundary motions using the immersed boundary method. At this preliminary stage, the 4-D MRI is used to provide an appropriate comparison. This allows flexible investigation of the flow features in the ventricles and their responses. Results: The results simulate various flow rates and kinetic energy in the diastole and systole phases, demonstrating the feasibility of capturing some of the important characteristics of the heart during different phases. However, some discrepancies exist in the pulmonary vein and aorta flow rate between the numerical and experimental data. Further studies are essential to investigate and solve the remaining problems before using the data in clinical diagnostics. Conclusions: The results show that by using a simple reservoir pressure boundary condition (RPBC), we are able to capture some essential variations found in the clinical data. Our approach establishes a first-step framework of a practical patient-specific CMS, which comprises a 3-D CFD model (without involving actual hemodynamic data yet) to simulate the heart and the 4-D PC-MRI system. At this stage, the 4-D PC-MRI system is used for verification purpose rather than input. This brings us closer to our goal of developing a practical patient-specific CMS, which will be pursued next. We anticipate that in the future, this hybrid system can potentially identify possible disease conditions in LV through comprehensive analysis and facilitates physicians in early diagnosis of probable cardiac problems. © 2011 Tay et al; licensee BioMed Central Ltd. | Source Title: | BioMedical Engineering Online | URI: | https://scholarbank.nus.edu.sg/handle/10635/181633 | ISSN: | 1475925X | DOI: | 10.1186/1475-925X-10-52 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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