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https://doi.org/10.3389/fnins.2011.00018
Title: | Role of neuronal Ras activity in adult hippocampal neurogenesis and cognition | Authors: | Manns, M Leske, O Gottfried, S Bichler, Z Lafenêtre, P Wahle, P Heumann, R |
Keywords: | 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine brain derived neurotrophic factor caspase 3 growth factor guanine nucleotide binding protein hormone messenger RNA neuropeptide neurotransmitter Ras protein behavior brain development cognition cognitive defect dentate gyrus exercise gene expression hippocampus memory nerve cell differentiation nervous system development nonhuman review short term memory transgenic mouse wild type |
Issue Date: | 2011 | Citation: | Manns, M, Leske, O, Gottfried, S, Bichler, Z, Lafenêtre, P, Wahle, P, Heumann, R (2011). Role of neuronal Ras activity in adult hippocampal neurogenesis and cognition. Frontiers in Neuroscience (FEB) : 18. ScholarBank@NUS Repository. https://doi.org/10.3389/fnins.2011.00018 | Rights: | Attribution 4.0 International | Abstract: | Hippocampal neurogenesis in the adult mammalian brain is modulated by various signals like growth factors, hormones, neuropeptides, and neurotransmitters. All of these factors can (but not necessarily do) converge on the activation of the G protein Ras. We used a transgenic mouse model (synRas mice) expressing constitutively activated G12V-Harvey Ras selectively in differentiated neurons to investigate the possible effects onto neurogenesis. H-Ras activation in neurons attenuates hippocampal precursor cell generation at an early stage of the proliferative cascade before neuronal lineage determination occurs. Therefore it is unlikely that the transgenically activated H-Ras in neurons mediates this effect by a direct, intracellular signaling mechanism. Voluntary exercise restores neurogenesis up to wild type level presumably mediated by brain-derived neurotrophic factor. Reduced neurogenesis is linked to impairments in spatial short-term memory and object recognition, the latter can be rescued by voluntary exercise, as well. These data support the view that new cells significantly increase complexity that can be processed by the hippocampal network when experience requires high demands to associate stimuli over time and/or space. © 2011 Manns, Leske, Gottfried, Bichler, Lafenêtre, Wahle and Heumann. | Source Title: | Frontiers in Neuroscience | URI: | https://scholarbank.nus.edu.sg/handle/10635/181620 | ISSN: | 16624548 | DOI: | 10.3389/fnins.2011.00018 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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