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https://doi.org/10.3389/fncir.2013.00160
| Title: | Next-generation transgenic mice for optogenetic analysis of neural circuits | Authors: | Asrican, B Augustine, G.J Berglund, K Chen, S Chow, N Deisseroth, K Feng, G Gloss, B Hira, R Hoffmann, C Kasai, H Katarya, M Kim, J Kudolo, J Lee, L.M Lo, S.Q Mancuso, J Matsuzaki, M Nakajima, R Qiu, L Tan, G Tang, Y Ting, J.T Tsuda, S Wen, L Zhang, X Zhao, S |
Keywords: | channelrhodopsin halorhodopsin rhodopsin unclassified drug rhodopsin channelrhodopsin amygdaloid nucleus animal cell article brain cortex brain function brain mapping cerebellum connectome controlled study fluorescence gene expression genetic analysis hippocampus in vitro study in vivo study limb movement medulla oblongata mesencephalon molecular genetics mouse nonhuman olfactory bulb optogenetics photoinhibition photostimulation pons promoter region septum pellucidum thalamus transgenic mouse action potential animal genetics nerve cell nerve cell network nerve tract optogenetics physiology procedures transgenic mouse cortex methodology nerve cell nerve cell network Action Potentials Animals Mice Mice, Transgenic Nerve Net Neural Pathways Neurons Optogenetics Rhodopsin cerebellum channelrhodopsin cortex hippocampus optogenetics photoinhibition photostimulation pons Action Potentials Animals Mice Mice, Transgenic Nerve Net Neural Pathways Neurons Optogenetics Rhodopsin |
Issue Date: | 2013 | Citation: | Asrican, B, Augustine, G.J, Berglund, K, Chen, S, Chow, N, Deisseroth, K, Feng, G, Gloss, B, Hira, R, Hoffmann, C, Kasai, H, Katarya, M, Kim, J, Kudolo, J, Lee, L.M, Lo, S.Q, Mancuso, J, Matsuzaki, M, Nakajima, R, Qiu, L, Tan, G, Tang, Y, Ting, J.T, Tsuda, S, Wen, L, Zhang, X, Zhao, S (2013). Next-generation transgenic mice for optogenetic analysis of neural circuits. Frontiers in Neural Circuits 7 (NOV) : 160. ScholarBank@NUS Repository. https://doi.org/10.3389/fncir.2013.00160 | Rights: | Attribution 4.0 International | Abstract: | Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice. © 2013 Asrican, Augustine. | Source Title: | Frontiers in Neural Circuits | URI: | https://scholarbank.nus.edu.sg/handle/10635/181539 | ISSN: | 16625110 | DOI: | 10.3389/fncir.2013.00160 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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