Please use this identifier to cite or link to this item: https://doi.org/10.3389/fpsyt.2014.00149
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dc.titleLong-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation
dc.contributor.authorMorgan, C.J.A
dc.contributor.authorDodds, C
dc.contributor.authorFurby, H
dc.contributor.authorPepper, F
dc.contributor.authorFam, J
dc.contributor.authorFreeman, T.P
dc.contributor.authorHughes, E
dc.contributor.authorDoeller, C
dc.contributor.authorKing, J
dc.contributor.authorHowes, O
dc.contributor.authorStone, J.M
dc.date.accessioned2020-10-27T11:12:14Z
dc.date.available2020-10-27T11:12:14Z
dc.date.issued2014
dc.identifier.citationMorgan, C.J.A, Dodds, C, Furby, H, Pepper, F, Fam, J, Freeman, T.P, Hughes, E, Doeller, C, King, J, Howes, O, Stone, J.M (2014). Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation. Frontiers in Psychiatry 5 (OCT) : 149. ScholarBank@NUS Repository. https://doi.org/10.3389/fpsyt.2014.00149
dc.identifier.issn16640640
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181525
dc.description.abstractKetamine, a non-competitive N-methyl-D-aspartate receptor antagonist, is rising in popularity as a drug of abuse. Preliminary evidence suggests that chronic, heavy ketamine use may have profound effects on spatial memory but the mechanism of these deficits is as yet unclear. This study aimed to examine the neural mechanism by which heavy ketamine use impairs spatial memory processing. In a sample of 11 frequent ketamine users and 15 polydrug controls, matched for IQ, age, years in education. We used fMRI utilising an ROI approach to examine the neural activity of three regions known to support successful navigation; the hippocampus, parahippocampal gyrus and the caudate nucleus during a virtual reality task of spatial memory. Frequent ketamine users displayed spatial memory deficits, accompanied by and related to, reduced activation in both the right hippocampus and left parahippocampal gyrus during navigation from memory, and in the left caudate during memory updating, compared to controls. Ketamine users also exhibited schizotypal and dissociative symptoms that were related to hippocampal activation. Impairments in spatial memory observed in ketamine users are related to changes in medial temporal lobe activation. Disrupted medial temporal lobe function may be a consequence of chronic ketamine abuse and may relate to schizophrenia-like symptomatology observed in ketamine users. © 2014 Morgan, Dodds, Furby, Pepper, Fam, Freeman, Hughes, Doeller, King, Stone and Howes.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectketamine
dc.subjectadult
dc.subjectArticle
dc.subjectbrain function
dc.subjectcaudate nucleus
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdissociative disorder
dc.subjectdrug misuse
dc.subjectdrug use
dc.subjectfemale
dc.subjectfunctional magnetic resonance imaging
dc.subjecthippocampus
dc.subjecthuman
dc.subjectmale
dc.subjectmemory disorder
dc.subjectmental task
dc.subjectneurotoxicity
dc.subjectparahippocampal gyrus
dc.subjectsample size
dc.subjectschizophrenia
dc.subjectschizotypal personality disorder
dc.subjectspatial memory
dc.subjecttemporal lobe
dc.typeArticle
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.description.doi10.3389/fpsyt.2014.00149
dc.description.sourcetitleFrontiers in Psychiatry
dc.description.volume5
dc.description.issueOCT
dc.description.page149
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