Please use this identifier to cite or link to this item:
https://doi.org/10.1186/1471-2415-14-123
Title: | Intraocular pressure rise is predictive of vision improvement after intravitreal triamcinolone acetonide for diabetic macular oedema: A retrospective analysis of data from a randomised controlled trial | Authors: | O'Day, R.F Barthelmes, D Zhu, M Wong, T.Y McAllister, I.L Arnold, J.J Gillies, M.C |
Keywords: | glucocorticoid glycosylated hemoglobin hemoglobin A1c protein, human triamcinolone acetonide aged controlled study diabetic retinopathy double blind procedure drug effects female human intraocular pressure intravitreal drug administration macular edema male metabolism middle aged pathophysiology physiology prospective study randomized controlled trial visual acuity Aged Diabetic Retinopathy Double-Blind Method Female Glucocorticoids Hemoglobin A, Glycosylated Humans Intraocular Pressure Intravitreal Injections Macular Edema Male Middle Aged Prospective Studies Triamcinolone Acetonide Visual Acuity |
Issue Date: | 2014 | Citation: | O'Day, R.F, Barthelmes, D, Zhu, M, Wong, T.Y, McAllister, I.L, Arnold, J.J, Gillies, M.C (2014). Intraocular pressure rise is predictive of vision improvement after intravitreal triamcinolone acetonide for diabetic macular oedema: A retrospective analysis of data from a randomised controlled trial. BMC Ophthalmology 14 (1) : 123. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2415-14-123 | Rights: | Attribution 4.0 International | Abstract: | Background: Intravitreal triamcinolone acetonide (IVTA) is an effective treatment for recalcitrant diabetic macular oedema (DMO). It has been shown to improve vision with benefits persisting up to five years. The most common initial side effect of IVTA treatment is rise in intraocular pressure, occurring in approximately 50% of patients within the first 6 months of treatment. We evaluated whether there is a correlation between the development of intraocular pressure rise and improvement in vision. Methods: Analysis of individual data from 33 eyes of 33 participants treated with IVTA for DMO from a prospective, randomised, double-masked, placebo controlled trial. The degree of intraocular pressure (IOP) rise was correlated with improvement in best-corrected visual acuity (BCVA) at 1 and 6 months. Results: The proportion of eyes gaining 5 or more logMAR letters was higher in eyes with greater IOP rise (p = 0.044). Better absolute improvement in BCVA at 6 months (p = 0.045) was also found in eyes with greater IOP rise. Regression analyses revealed a correlation between IOP rise of 10 or more mmHg and absolute BCVA improvement at 6 months (odds ratio 1.22, 95% confidence interval 1.01-1.48, p = 0.039), but not at 1 month. Conclusions: IOP rise and vision improvement appear to be correlated following IVTA for DMO, suggesting that the mechanisms that cause both may be linked. Trial Registration: Clinical trials.gov NCT00167518, September 5, 2005. © 2014 O'Day et al. | Source Title: | BMC Ophthalmology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181519 | ISSN: | 14712415 | DOI: | 10.1186/1471-2415-14-123 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1186_1471-2415-14-123.pdf | 258.79 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License