Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2334-14-93
Title: TB incidence and characteristics in the remote gulf province of Papua New Guinea: A prospective study
Authors: Cross, G.B 
Coles, K
Nikpour, M
Moore, O.A
Denholm, J
McBryde, E.S
Eisen, D.P
Warigi, B
Carter, R
Pandey, S
Harino, P
Siba, P
Coulter, C
Mueller, I
Phuanukoonnon, S
Pellegrini, M
Keywords: rifampicin
tuberculostatic agent
adolescent
adult
antibiotic resistance
article
bacterial strain
bacterium isolate
child
clinical feature
comorbidity
disease transmission
female
genetic analysis
genetic variability
genotype
human
Human immunodeficiency virus infection
major clinical study
male
mixed infection
molecular diagnostics
morbidity
nonhuman
observational study
outcome assessment
Papua New Guinea
prospective study
rural population
sputum culture
sputum cytodiagnosis
tuberculosis
allele
complication
epidemiology
incidence
microbiology
middle aged
preschool child
risk factor
sputum
tuberculosis
Tuberculosis, Multidrug-Resistant
young adult
Adolescent
Adult
Alleles
Antitubercular Agents
Child
Child, Preschool
Coinfection
Female
Genotype
HIV Infections
Humans
Incidence
Male
Middle Aged
Papua New Guinea
Prospective Studies
Rifampin
Risk Factors
Sputum
Tuberculosis
Tuberculosis, Multidrug-Resistant
Young Adult
Issue Date: 2014
Citation: Cross, G.B, Coles, K, Nikpour, M, Moore, O.A, Denholm, J, McBryde, E.S, Eisen, D.P, Warigi, B, Carter, R, Pandey, S, Harino, P, Siba, P, Coulter, C, Mueller, I, Phuanukoonnon, S, Pellegrini, M (2014). TB incidence and characteristics in the remote gulf province of Papua New Guinea: A prospective study. BMC Infectious Diseases 14 (1) : 93. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2334-14-93
Rights: Attribution 4.0 International
Abstract: Background: The incidence and characteristics of tuberculosis (TB) in remote areas of Papua New Guinea (PNG) are largely unknown. The purpose of our study was to determine the incidence of TB in the Gulf Province of PNG and describe disease characteristics, co-morbidities and drug resistance profiles that could impact on disease outcomes and transmission.Methods: Between March 2012 and June 2012, we prospectively collected data on 274 patients presenting to Kikori Hospital with a presumptive diagnosis of TB, and on hospital inpatients receiving TB treatment during the study period. Sputum was collected for microscopy, GeneXpert analysis, culture and genotyping of isolates.Results: We estimate the incidence of TB in Kikori to be 1290 per 100,000 people (95% CI 1140 to 1460) in 2012. The proportion of TB patients co-infected with HIV was 1.9%. Three of 32 TB cases tested were rifampicin resistant. Typing of nine isolates demonstrated allelic diversity and most were related to Beijing strains.Conclusions: The incidence of TB in Kikori is one of the highest in the world and it is not driven by HIV co-infection. The high incidence and the presence of rifampicin resistant warrant urgent attention to mitigate substantial morbidity in the region. © 2014 Cross et al.; licensee BioMed Central Ltd.
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181509
ISSN: 14712334
DOI: 10.1186/1471-2334-14-93
Rights: Attribution 4.0 International
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