Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2180-14-51
Title: Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens
Authors: Deng, Y
Lim, A
Lee, J
Chen, S
An, S
Dong, Y.-H
Zhang, L.-H 
Keywords: 11 methyl 2 dodecenoic acid
ampicillin
antibiotic agent
chloramphenicol
gentamicin
kanamycin
medium chain fatty acid
rifampicin
tetracycline
trimethoprim
unclassified drug
unsaturated fatty acid
antibiotic resistance
antibiotic sensitivity
article
Bacillus cereus
Bacillus thuringiensis
bacterial growth
bacterial virulence
biofilm
controlled study
drug potentiation
female
growth rate
human
human cell
minimum inhibitory concentration
Mycobacterium smegmatis
Neisseria
neisseria subflava
nonhuman
Pseudomonas aeruginosa
quorum sensing
Staphylococcus aureus
Bacillus cereus
Bacillus thuringiensis
Bacteria (microorganisms)
Mycobacterium smegmatis
Neisseria subflava
Pseudomonas aeruginosa
Staphylococcus aureus
Anti-Bacterial Agents
Dose-Response Relationship, Drug
Drug Synergism
Gentamicins
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Lauric Acids
Quorum Sensing
Issue Date: 2014
Citation: Deng, Y, Lim, A, Lee, J, Chen, S, An, S, Dong, Y.-H, Zhang, L.-H (2014). Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens. BMC Microbiology 14 (1) : 51. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2180-14-51
Rights: Attribution 4.0 International
Abstract: Background: Extensive use of antibiotics has fostered the emergence of superbugs that are resistant to multidrugs, which becomes a great healthcare and public concern. Previous studies showed that quorum sensing signal DSF (diffusible signal factor) not only modulates bacterial antibiotic resistance through intraspecies signaling, but also affects bacterial antibiotic tolerance through interspecies communication. These findings motivate us to exploit the possibility of using DSF and its structurally related molecules as adjuvants to influence antibiotic susceptibility of bacterial pathogens. Results: In this study, we have demonstrated that DSF signal and its structurally related molecules could be used to induce bacterial antibiotic susceptibility. Exogenous addition of DSF signal (cis-11-methyl-2-dodecenoic acid) and its structural analogues could significantly increase the antibiotic susceptibility of Bacillus cereus, possibly through reducing drug-resistant activity, biofilm formation and bacterial fitness. The synergistic effect of DSF and its structurally related molecules with antibiotics on B. cereus is dosage-dependent. Combination of DSF with gentamicin showed an obviously synergistic effect on B. cereus pathogenicity in an in vitro model. We also found that DSF could increase the antibiotic susceptibility of other bacterial species, including Bacillus thuringiensis, Staphylococcus aureus, Mycobacterium smegmatis, Neisseria subflava and Pseudomonas aeruginosa. Conclusion: The results indicate a promising potential of using DSF and its structurally related molecules as novel adjuvants to conventional antibiotics for treatment of infectious diseases caused by bacterial pathogens. © 2014 Deng et al.; licensee BioMed Central Ltd.
Source Title: BMC Microbiology
URI: https://scholarbank.nus.edu.sg/handle/10635/181507
ISSN: 14712180
DOI: 10.1186/1471-2180-14-51
Rights: Attribution 4.0 International
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