Please use this identifier to cite or link to this item: https://doi.org/10.3389/fncel.2015.00064
Title: SIRT1 in the brain—connections with aging-associated disorders and lifespan
Authors: Ng, F
Wijaya, L
Tang, B.L 
Keywords: cyclic AMP responsive element binding protein
histone deacetylase
sirtuin 1
somatomedin C
aging
astrocytosis
circadian rhythm
cognition
down regulation
energy metabolism
lifespan
nerve cell degeneration
nerve cell network
nerve cell plasticity
nerve degeneration
nerve fiber growth
neuroprotection
protein expression
Review
upregulation
Issue Date: 2015
Citation: Ng, F, Wijaya, L, Tang, B.L (2015). SIRT1 in the brain—connections with aging-associated disorders and lifespan. Frontiers in Cellular Neuroscience 9 : 64. ScholarBank@NUS Repository. https://doi.org/10.3389/fncel.2015.00064
Rights: Attribution 4.0 International
Abstract: The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1’s role that impinges on aging and lifespan may lie in its activities in the central nervous system (CNS) neurons. Systemically, SIRT1 influences energy metabolism and circadian rhythm through its activity in the hypothalamic nuclei. From a cell biological perspective, SIRT1 is a crucial component of multiple interconnected regulatory networks that modulate dendritic and axonal growth, as well as survival against stress. This neuronal cell autonomous activity of SIRT1 is also important for neuronal plasticity, cognitive functions, as well as protection against aging-associated neuronal degeneration and cognitive decline. We discuss recent findings that have shed light on the various activities of SIRT1 in the brain, which collectively impinge on agingassociated disorders and lifespan. © 2015 Ng, Wijaya and Tang.
Source Title: Frontiers in Cellular Neuroscience
URI: https://scholarbank.nus.edu.sg/handle/10635/181457
ISSN: 16625102
DOI: 10.3389/fncel.2015.00064
Rights: Attribution 4.0 International
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