Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnagi.2017.00361
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dc.titleAsymmetry of hemispheric network topology reveals dissociable processes between functional and structural brain connectome in community-living elders
dc.contributor.authorSun, Y
dc.contributor.authorLi, J
dc.contributor.authorSuckling, J
dc.contributor.authorFeng, L
dc.date.accessioned2020-10-27T10:18:53Z
dc.date.available2020-10-27T10:18:53Z
dc.date.issued2017
dc.identifier.citationSun, Y, Li, J, Suckling, J, Feng, L (2017). Asymmetry of hemispheric network topology reveals dissociable processes between functional and structural brain connectome in community-living elders. Frontiers in Aging Neuroscience 9 (NOV) : 361. ScholarBank@NUS Repository. https://doi.org/10.3389/fnagi.2017.00361
dc.identifier.issn16634365
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181239
dc.description.abstractHuman brain is structurally and functionally asymmetrical and the asymmetries of brain phenotypes have been shown to change in normal aging. Recent advances in graph theoretical analysis have showed topological lateralization between hemispheric networks in the human brain throughout the lifespan. Nevertheless, apparent discrepancies of hemispheric asymmetry were reported between the structural and functional brain networks, indicating the potentially complex asymmetry patterns between structural and functional networks in aging population. In this study, using multimodal neuroimaging (resting-state fMRI and structural diffusion tensor imaging), we investigated the characteristics of hemispheric network topology in 76 (male/female = 15/61, age = 70.08 ± 5.30 years) community-dwelling older adults. Hemispheric functional and structural brain networks were obtained for each participant. Graph theoretical approaches were then employed to estimate the hemispheric topological properties. We found that the optimal small-world properties were preserved in both structural and functional hemispheric networks in older adults. Moreover, a leftward asymmetry in both global and local levels were observed in structural brain networks in comparison with a symmetric pattern in functional brain network, suggesting a dissociable process of hemispheric asymmetry between structural and functional connectome in healthy older adults. Finally, the scores of hemispheric asymmetry in both structural and functional networks were associated with behavioral performance in various cognitive domains. Taken together, these findings provide new insights into the lateralized nature of multimodal brain connectivity, highlight the potentially complex relationship between structural and functional brain network alterations, and augment our understanding of asymmetric structural and functional specializations in normal aging. © 2017 Sun, Li, Suckling and Feng.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectaged
dc.subjectaging
dc.subjectbrain asymmetry
dc.subjectcommunity living
dc.subjectconnectome
dc.subjectcontrolled study
dc.subjectdiffusion tensor imaging
dc.subjectdissociation
dc.subjectfemale
dc.subjectfunctional magnetic resonance imaging
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectmale
dc.subjectneuroimaging
dc.subjectrest
dc.subjectspecialization
dc.subjectstructure activity relation
dc.typeArticle
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.description.doi10.3389/fnagi.2017.00361
dc.description.sourcetitleFrontiers in Aging Neuroscience
dc.description.volume9
dc.description.issueNOV
dc.description.page361
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