Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12882-018-0976-4
Title: Varicella infections in patients with end stage renal disease: A systematic review
Authors: Ong, C.Y
Low, S.G
Vasanwala, F.F 
Baikunje, S
Low, L.L
Keywords: aciclovir
foscarnet
ganciclovir
immunoglobulin
valaciclovir
Article
cause of death
chronic kidney failure
disease association
end stage renal disease
graft recipient
hemodialysis
herpes zoster
human
immunogenicity
kidney transplantation
morbidity
mortality
population research
practice guideline
seroconversion
seroprevalence
systematic review
vaccination
Issue Date: 2018
Citation: Ong, C.Y, Low, S.G, Vasanwala, F.F, Baikunje, S, Low, L.L (2018). Varicella infections in patients with end stage renal disease: A systematic review. BMC Nephrology 19 (1) : 185. ScholarBank@NUS Repository. https://doi.org/10.1186/s12882-018-0976-4
Rights: Attribution 4.0 International
Abstract: Background: End stage renal disease (ESRD) is on the rise globally. Varicella infection among adult patients with ESRD has been reported to lead to multiple complications and even death. While varicella vaccination has been recommended in paediatric renal patients; recommendation on varicella vaccination among adult patients with ESRD remained sparse. This review is aimed at evaluating the impact of varicella infection among adult patients with ESRD and make a recommendation for vaccination. Methods: Three databases (PubMed, Embase and Cumulative Index to Nursing and Allied Health Literature (CINAHL)) were searched in April 2018 with keywords 'varicella, chronic kidney failure, chronic kidney disease, renal replacement therapy, kidney transplantation, end stage renal disease, end stage renal failure, chicken pox, vaccine, vaccination and complications'. Results: 29 articles were selected for review. The studies were mainly case reports, and they included measured outcomes: prevalence of seronegativity, impact (morbidity, length of stay, and mortality) of varicella among patients with ESRD, seroconversion rates and safety of varicella vaccination. The prevalence of seronegativity among varicella-infected ESRD adults was found to be at 42 to 100%. Nineteen deaths were reported. At least 54 patients have had complications from varicella infection. Seroconversion rate post vaccination was found to be around 64-94%. Conclusion: Varicella is associated with significant morbidity and mortality rates in adult patients with ESRD. Varicella vaccination should be considered for the vulnerable, seronegative patients. © 2018 The Author(s).
Source Title: BMC Nephrology
URI: https://scholarbank.nus.edu.sg/handle/10635/181187
ISSN: 14712369
DOI: 10.1186/s12882-018-0976-4
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1186_s12882-018-0976-4.pdf918.78 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

3
checked on Oct 11, 2021

Page view(s)

77
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons