Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12872-018-0894-1
Title: Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes
Authors: Marks, E.C.A
Wilkinson, T.M
Frampton, C.M
Skelton, L
Pilbrow, A.P
Yandle, T.G
Pemberton, C.J
Doughty, R.N
Whalley, G.A
Ellis, C.J
Troughton, R.W
Owen, M.C
Pattinson, N.R
Cameron, V.A
Richards, A.M 
Gieseg, S.P
Palmer, B.R
Keywords: neopterin
unclassified drug
vasculotropin receptor
vasculotropin receptor sFlt 1
vasculotropin receptor sKDR
FLT1 protein, human
KDR protein, human
pterin derivative
vasculotropin receptor 1
vasculotropin receptor 2
acute coronary syndrome
age
aged
alcohol consumption
all cause mortality
allele
Article
body mass
cohort analysis
female
gene
genetic marker
genetic variability
genotype
human
human cell
macrophage activation
major clinical study
male
pathophysiology
predictor variable
priority journal
proportional hazards model
prospective study
protein blood level
single nucleotide polymorphism
VEGFR 1 gene
VEGFR 2 gene
acute coronary syndrome
blood
coronary angiography
diagnostic imaging
drinking behavior
genetic association study
genetic predisposition
genetics
macrophage
macrophage activation
metabolism
mortality
phenotype
predictive value
prognosis
risk factor
Acute Coronary Syndrome
Age Factors
Aged
Alcohol Drinking
Coronary Angiography
Female
Genetic Association Studies
Genetic Markers
Genetic Predisposition to Disease
Humans
Macrophage Activation
Macrophages
Male
Phenotype
Polymorphism, Single Nucleotide
Predictive Value of Tests
Prognosis
Pterins
Risk Factors
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Issue Date: 2018
Citation: Marks, E.C.A, Wilkinson, T.M, Frampton, C.M, Skelton, L, Pilbrow, A.P, Yandle, T.G, Pemberton, C.J, Doughty, R.N, Whalley, G.A, Ellis, C.J, Troughton, R.W, Owen, M.C, Pattinson, N.R, Cameron, V.A, Richards, A.M, Gieseg, S.P, Palmer, B.R (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders 18 (1) : 169. ScholarBank@NUS Repository. https://doi.org/10.1186/s12872-018-0894-1
Rights: Attribution 4.0 International
Abstract: Background: Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages. In patients from a prospectively recruited post-acute coronary syndromes cohort we investigated the prognostic performance of three products of activated macrophages, soluble vascular endothelial growth factor (VEGF) receptors (sFlt-1 and sKDR) and pterins, alongside genetic variants in VEGF receptor genes, VEGFR-1 and VEGFR-2. Methods: Baseline levels of sFlt-1 (VEGFR1), sKDR (VEGFR2) and pterins were measured in plasma samples from subgroups (n = 513; 211; 144, respectively) of the Coronary Disease Cohort Study (CDCS, n = 2067). DNA samples from the cohort were genotyped for polymorphisms from the VEGFR-1 gene SNPs (rs748252 n = 2027, rs9513070 n = 2048) and VEGFR-2 gene SNPs (rs2071559 n = 2050, rs2305948 n = 2066, rs1870377 n = 2042). Results: At baseline, levels of sFlt-1 were significantly correlated with age, alcohol consumption, NTproBNP, BNP and other covariates relevant to cardiovascular pathophysiology. Total neopterin levels were associated with alcohol consumption at baseline. 7,8 dihydroneopterin was associated with BMI. The A allele of VEGFR-2 variant rs1870377 was associated with higher plasma sFlt-1 and lower levels of sKDR at baseline. Baseline plasma sFlt-1 was univariately associated with all cause mortality with (p < 0.001) and in a Cox's proportional hazards regression model sFlt-1 and pterins were both associated with mortality independent of established predictors (p < 0.027). Conclusions: sFlt-1 and pterins may have potential as prognostic biomarkers in acute coronary syndromes patients. Genetic markers from VEGF system genes warrant further investigation as markers of levels of VEGF system components in these patients. © 2018 The Author(s).
Source Title: BMC Cardiovascular Disorders
URI: https://scholarbank.nus.edu.sg/handle/10635/181184
ISSN: 14712261
DOI: 10.1186/s12872-018-0894-1
Rights: Attribution 4.0 International
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