Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.00276
Title: Prolyl isomerase Pin1: A catalyst for oncogenesis and a potential therapeutic target in cancer
Authors: Ryo, A
Liou, Y.-C 
Lu, K.P
Wulf, G
Keywords: antineoplastic agent
APC protein
beta catenin
cis trans isomerase
cyclin D1
DNA
juglone
phosphoprotein
proline derivative
protein p53
protein Pin 1
Ras protein
serine
threonine
transcription factor E2F
unclassified drug
Wnt protein
breast cell
carcinogenesis
cell growth
cell transformation
cis trans isomerism
conformational transition
DNA damage
drug mechanism
drug targeting
gene expression regulation
gene overexpression
human
mitogenicity
nonhuman
oncogene neu
oncogene ras
priority journal
protein function
protein motif
protein phosphorylation
protein protein interaction
protein stability
regulatory mechanism
review
signal transduction
transcription regulation
Animals
Antineoplastic Agents
beta Catenin
Catalysis
Cyclin D1
Cytoskeletal Proteins
DNA Damage
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Neoplasms
Peptidylprolyl Isomerase
Signal Transduction
Trans-Activators
Tumor Suppressor Protein p53
Issue Date: 2003
Citation: Ryo, A, Liou, Y.-C, Lu, K.P, Wulf, G (2003). Prolyl isomerase Pin1: A catalyst for oncogenesis and a potential therapeutic target in cancer. Journal of Cell Science 116 (5) : 773-783. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.00276
Rights: Attribution 4.0 International
Abstract: Phosphorylation of proteins on serine or threonine residues preceding proline (Ser/Thr-Pro) is a major intracellular signaling mechanism. The phosphorylated Ser/Thr-Pro motifs in a certain subset of phosphoproteins; are isomerized specifically by the peptidyl-prolyl cis-trans isomerase Pin1. This post-phosphorylation isomerization can lead to conformational changes in the substrate proteins and modulate their functions. Pin1 interacts with a number of mitotic phosphoproteins, and plays a critical role in mitotic regulation. Recent work indicates that Pin1 is overexpressed in many human cancers and plays an important role in oncogenesis. Pin1 regulates the expression of cyclin D1 by cooperating with Ras signaling and inhibiting the interaction of ?-catenin with the tumor suppressor APC and also directly stabilizing cyclin D1 protein. Furthermore, PIN1 is an E2F target gene essential for the Neu/Ras-induced transformation of mammary epithelial cells. Pin1 is also a critical regulator of the tumor suppressor p53 during DNA damage response. Given its role in cell growth control and oncogenesis, Pin1 could represent a new anti-cancer target.
Source Title: Journal of Cell Science
URI: https://scholarbank.nus.edu.sg/handle/10635/181126
ISSN: 00219533
DOI: 10.1242/jcs.00276
Rights: Attribution 4.0 International
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