Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid0904.020395
Title: Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: Comparative analysis of the VP1 and VP4 genes
Authors: Cardosa, M.J
Perera, D
Brown, B.A
Cheon, D
Chan, H.M
Chan, K.P 
Cho, H
McMinn, P
Keywords: article
Asia
Australia
Enterovirus
epidemic
hand foot and mouth disease
human
Korea
Malaysia
nonhuman
phylogeny
Singapore
Taiwan
virus gene
virus strain
vp1 gene
VP4 gene
Enterovirus infection
epidemic
epidemiology
genetics
genotype
isolation and purification
methodology
pathogenicity
phylogeny
review
Southeast Asia
Asia, Southeastern
Disease Outbreaks
Enterovirus
Enterovirus Infections
Epidemiology, Molecular
Genotype
Humans
Phylogeny
Issue Date: 2003
Publisher: Centers for Disease Control and Prevention (CDC)
Citation: Cardosa, M.J, Perera, D, Brown, B.A, Cheon, D, Chan, H.M, Chan, K.P, Cho, H, McMinn, P (2003). Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: Comparative analysis of the VP1 and VP4 genes. Emerging Infectious Diseases 9 (4) : 461-468. ScholarBank@NUS Repository. https://doi.org/10.3201/eid0904.020395
Rights: Attribution 4.0 International
Abstract: This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3.
Source Title: Emerging Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181124
ISSN: 10806040
DOI: 10.3201/eid0904.020395
Rights: Attribution 4.0 International
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