Please use this identifier to cite or link to this item: https://doi.org/10.2337/diacare.27.9.2166
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dc.titleEffect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects
dc.contributor.authorManning, P.J
dc.contributor.authorSutherland, W.H.F
dc.contributor.authorWalker, R.J
dc.contributor.authorWilliams, S.M
dc.contributor.authorDe Jong, S.A
dc.contributor.authorRyalls, A.R
dc.contributor.authorBerry, E.A
dc.date.accessioned2020-10-27T09:51:16Z
dc.date.available2020-10-27T09:51:16Z
dc.date.issued2004
dc.identifier.citationManning, P.J, Sutherland, W.H.F, Walker, R.J, Williams, S.M, De Jong, S.A, Ryalls, A.R, Berry, E.A (2004). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care 27 (9) : 2166-2171. ScholarBank@NUS Repository. https://doi.org/10.2337/diacare.27.9.2166
dc.identifier.issn01495992
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181105
dc.description.abstractOBJECTIVE - Markers of oxidative stress and plasma alanine transferase (ALT) levels are increased and circulating antioxidant concentrations are reduced in individuals with insulin resistance. Vitamin E improves glycemic control in people with diabetes. We tested the hypothesis that vitamin E would decrease markers of oxidative stress and plasma ALT levels and improve insulin sensitivity in overweight individuals. RESEARCH DESIGN AND METHODS - Eighty overweight individuals (BMI >27 kg/m2) were randomly allocated to receive either 800 IU vitamin E per day or a matching placebo for 3 months. The dose of vitamin E was increased to 1,200 IU per day for a further 3 months. RESULTS - Plasma peroxides decreased by 27% at 3 months and by 29% at 6 months in the group that received vitamin E and were positively correlated with plasma vitamin E concentrations at the 6-month time point. At 3 months, fasting plasma glucose and insulin concentrations were significantly reduced and homeostasis model assessment increased. These changes were not apparent at 6 months. Plasma ALT concentrations declined significantly throughout the study period. CONCLUSIONS - In conclusion, these findings indicate that vitamin E improves oxidative stress and hepatocellular function. Although insulin resistance also improves, this effect appears transient.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectalanine aminotransferase
dc.subjectalpha tocopherol
dc.subjectfatty acid
dc.subjectglucose
dc.subjectinsulin
dc.subjectperoxide
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectarticle
dc.subjectclinical trial
dc.subjectconcentration response
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdiabetes mellitus
dc.subjectdose time effect relation
dc.subjectenzyme blood level
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectinsulin blood level
dc.subjectinsulin resistance
dc.subjectinsulin response
dc.subjectliver cell
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobesity
dc.subjectoxidative stress
dc.subjectrandomized controlled trial
dc.subjectstatistical significance
dc.subjectvitamin intake
dc.subjectAdult
dc.subjectAged
dc.subjectAntioxidants
dc.subjectBlood Glucose
dc.subjectBody Mass Index
dc.subjectC-Reactive Protein
dc.subjectEnzymes
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPlacebos
dc.subjectReference Values
dc.subjectVitamin E
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.2337/diacare.27.9.2166
dc.description.sourcetitleDiabetes Care
dc.description.volume27
dc.description.issue9
dc.description.page2166-2171
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