Please use this identifier to cite or link to this item:
https://doi.org/10.1210/jc.2004-0046
DC Field | Value | |
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dc.title | The skeletal phenotype of men with previous constitutional delay of puberty | |
dc.contributor.author | Yap, F | |
dc.contributor.author | Högler, W | |
dc.contributor.author | Briody, J | |
dc.contributor.author | Moore, B | |
dc.contributor.author | Howman-Giles, R | |
dc.contributor.author | Cowell, C.T | |
dc.date.accessioned | 2020-10-27T09:51:02Z | |
dc.date.available | 2020-10-27T09:51:02Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Yap, F, Högler, W, Briody, J, Moore, B, Howman-Giles, R, Cowell, C.T (2004). The skeletal phenotype of men with previous constitutional delay of puberty. Journal of Clinical Endocrinology and Metabolism 89 (9) : 4306-4311. ScholarBank@NUS Repository. https://doi.org/10.1210/jc.2004-0046 | |
dc.identifier.issn | 0021972X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181104 | |
dc.description.abstract | It is presently unclear whether men with a history of constitutional delay (CD) of puberty are osteopenic. This study compares auxology, bone mass, size, and density of 32 men (age, 21-33 yr) with previous CD with 45 controls. Using dual-energy x-ray absorptiometry, areal bone mineral density (aBMD) and volumetric bone mineral density at the lumbar spine (LS) and femoral neck (FN), hip strength analysis, and total-body and body segment (arms, legs, trunk) measurements were determined. Auxological variables, body composition, the muscle-bone relation, and the effect of prior androgen treatment were studied. Men with previous CD were shorter (P < 0.001) and had shorter height-adjusted arms compared with controls. Height-adjusted total-body bone mineral content (BMC) (P = 0.004), aBMD (P = 0.016), and bone area (P = 0.006) but not lean tissue mass (P = 0.507) were lower in CD men compared with controls; consequently, their BMC to lean tissue mass ratio was reduced (P < 0.001). Segment length-adjusted BMC and bone area of arms (P < 0.001) and legs (P < 0.03), but not trunk were lower in CD men than in controls. They had lower LS aBMD (P = 0.044) but normal LS and FN volumetric bone mineral density. Size-adjusted LS width and the hip cross-sectional area were lower than in controls. There was no difference in anthropometric or dual-energy x-ray absorptiometry results between untreated (n = 15) and androgen-treated (n = 17) CD men. We conclude that men with previous CD have normal LS and FN volumetric density but reduced total-body bone mass, which was explained by reduced limb bone mass and size. Together with the reduced LS bone width and hip cross-sectional area, these skeletal characteristics suggest impaired periosteal expansion during puberty. The skeletal phenotype of CD males may be altered by their late onset of puberty. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | oxandrolone | |
dc.subject | testosterone | |
dc.subject | adult | |
dc.subject | anthropometry | |
dc.subject | arm | |
dc.subject | article | |
dc.subject | body composition | |
dc.subject | body height | |
dc.subject | body mass | |
dc.subject | bone density | |
dc.subject | bone mineral | |
dc.subject | bone strength | |
dc.subject | clinical article | |
dc.subject | controlled study | |
dc.subject | delayed puberty | |
dc.subject | dual energy X ray absorptiometry | |
dc.subject | femur neck | |
dc.subject | hip | |
dc.subject | human | |
dc.subject | lean body weight | |
dc.subject | leg | |
dc.subject | lumbar spine | |
dc.subject | male | |
dc.subject | morphological trait | |
dc.subject | priority journal | |
dc.subject | skeletal muscle | |
dc.subject | trunk | |
dc.subject | volumetry | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Age Factors | |
dc.subject | Androgens | |
dc.subject | Bone Density | |
dc.subject | Femur Neck | |
dc.subject | Humans | |
dc.subject | Lumbar Vertebrae | |
dc.subject | Male | |
dc.subject | Phenotype | |
dc.subject | Puberty | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1210/jc.2004-0046 | |
dc.description.sourcetitle | Journal of Clinical Endocrinology and Metabolism | |
dc.description.volume | 89 | |
dc.description.issue | 9 | |
dc.description.page | 4306-4311 | |
Appears in Collections: | Elements Staff Publications |
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