Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13041-014-0092-8
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dc.titleProtein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression
dc.contributor.authorErkens, M
dc.contributor.authorTanaka-Yamamoto, K
dc.contributor.authorCheron, G
dc.contributor.authorMárquez-Ruiz, J
dc.contributor.authorPrigogine, C
dc.contributor.authorSchepens, J.T
dc.contributor.authorNadif Kasri, N
dc.contributor.authorAugustine, G.J
dc.contributor.authorHendriks, W.J
dc.date.accessioned2020-10-27T05:42:45Z
dc.date.available2020-10-27T05:42:45Z
dc.date.issued2015
dc.identifier.citationErkens, M, Tanaka-Yamamoto, K, Cheron, G, Márquez-Ruiz, J, Prigogine, C, Schepens, J.T, Nadif Kasri, N, Augustine, G.J, Hendriks, W.J (2015). Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Molecular brain 8 : 1. ScholarBank@NUS Repository. https://doi.org/10.1186/s13041-014-0092-8
dc.identifier.issn17566606
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180920
dc.description.abstractBACKGROUND: Regulation of synaptic connectivity, including long-term depression (LTD), allows proper tuning of cellular signalling processes within brain circuitry. In the cerebellum, a key centre for motor coordination, a positive feedback loop that includes mitogen-activated protein kinases (MAPKs) is required for proper temporal control of LTD at cerebellar Purkinje cell synapses. Here we report that the tyrosine-specific MAPK-phosphatase PTPRR plays a role in coordinating the activity of this regulatory loop.RESULTS: LTD in the cerebellum of Ptprr (-/-) mice is strongly impeded, in vitro and in vivo. Comparison of basal phospho-MAPK levels between wild-type and PTPRR deficient cerebellar slices revealed increased levels in mutants. This high basal phospho-MAPK level attenuated further increases in phospho-MAPK during chemical induction of LTD, essentially disrupting the positive feedback loop and preventing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) phosphorylation and endocytosis.CONCLUSIONS: Our findings indicate an important role for PTPRR in maintaining low basal MAPK activity in Purkinje cells. This creates an optimal 'window' to boost MAPK activity following signals that induce LTD, which can then propagate through feed-forward signals to cause AMPAR internalization and LTD.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectAMPA receptor
dc.subjectglutamate receptor ionotropic, AMPA 2
dc.subjectmitogen activated protein kinase
dc.subjectmitogen activated protein kinase kinase
dc.subjectprotein tyrosine kinase
dc.subjectPtprr protein, mouse
dc.subjectreceptor like protein tyrosine phosphatase
dc.subjectanimal
dc.subjectbiological model
dc.subjectC57BL mouse
dc.subjectcerebellum
dc.subjectdeficiency
dc.subjectelectrostimulation
dc.subjectfeedback system
dc.subjectfemale
dc.subjectknockout mouse
dc.subjectlong term depression
dc.subjectmale
dc.subjectmetabolism
dc.subjectmouse mutant
dc.subjectphosphorylation
dc.subjectPurkinje cell
dc.subjectsynapse
dc.subjectvibrissa
dc.subjectAnimals
dc.subjectCerebellum
dc.subjectElectric Stimulation
dc.subjectExtracellular Signal-Regulated MAP Kinases
dc.subjectFeedback, Physiological
dc.subjectFemale
dc.subjectLong-Term Synaptic Depression
dc.subjectMale
dc.subjectMice, Inbred C57BL
dc.subjectMice, Knockout
dc.subjectMice, Neurologic Mutants
dc.subjectMitogen-Activated Protein Kinase Kinases
dc.subjectModels, Biological
dc.subjectPhosphorylation
dc.subjectPurkinje Cells
dc.subjectReceptor-Like Protein Tyrosine Phosphatases, Class 7
dc.subjectReceptors, AMPA
dc.subjectsrc-Family Kinases
dc.subjectSynapses
dc.subjectVibrissae
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1186/s13041-014-0092-8
dc.description.sourcetitleMolecular brain
dc.description.volume8
dc.description.page1
dc.published.statePublished
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