Please use this identifier to cite or link to this item: https://doi.org/10.1155/2012/402109
Title: Occurrence of comorbidities before and after soft tissue sarcoma diagnosis
Authors: Van Herk-Sukel, M.P.P
Shantakumar, S 
Overbeek, L.I.H
Van Boven, H
Penning-Van Beest, F.J.A
Herings, R.M.C
Keywords: adult
aged
anemia
article
cancer diagnosis
cardiovascular disease
comorbidity
controlled study
data base
depression
diabetes mellitus
drug use
female
follow up
hospitalization
human
incidence
major clinical study
male
Netherlands
priority journal
register
respiratory tract disease
soft tissue sarcoma
Issue Date: 2012
Citation: Van Herk-Sukel, M.P.P, Shantakumar, S, Overbeek, L.I.H, Van Boven, H, Penning-Van Beest, F.J.A, Herings, R.M.C (2012). Occurrence of comorbidities before and after soft tissue sarcoma diagnosis. Sarcoma 2012 : 402109. ScholarBank@NUS Repository. https://doi.org/10.1155/2012/402109
Rights: Attribution 4.0 International
Abstract: Background. Data is limited on the burden of common comorbidities, such as cardiovascular disease (CVD), respiratory disease and diabetes, or comorbidities related to cancer and its treatment, such as anemia and depression, in patients with soft tissue sarcoma (STS). Patients and Methods. From the Dutch Pathology Registry linked to the PHARMO database (including data on drug use and hospitalizations), 533 patients with STS were selected during 2000-2007 and matched 1-:-10 to cancer-free controls. The occurrences of comorbidities were assessed in the 12 months before and after STS diagnosis. Results. STS patients were 2-4 times more likely to have comorbidities at diagnosis compared with cancer-free controls. The incidence of CVD, anemia, and depression after STS diagnosis differed significantly from cancer-free controls and decreased during followup from 40-124 per 1,000 person-years (py) during the first six months to 11-38 per 1,000py more than 12 months after diagnosis. The incidence of respiratory disease and diabetes among STS patients remained stable during followup (5-21 per 1,000py) and did not differ significantly from cancer-free controls. Conclusions. STS patients were more likely to have comorbidities before cancer diagnosis and to develop CVD, anemia, and depression after diagnosis compared to cancer-free controls. Copyright © 2012 Myrthe P. P. van Herk-Sukel et al.
Source Title: Sarcoma
URI: https://scholarbank.nus.edu.sg/handle/10635/180832
ISSN: 1357-714X
DOI: 10.1155/2012/402109
Rights: Attribution 4.0 International
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