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Title: The evolutionary history of R2R3-myb proteins across 50 eukaryotes: New insights into subfamily classification and expansion
Authors: Du, H
Liang, Z 
Zhao, S
Nan, M.-G
Tran, L.-S.P
Lu, K
Huang, Y.-B
Li, J.-N
Keywords: transcription factor
amino acid sequence
factual database
molecular evolution
molecular genetics
multigene family
sequence alignment
sequence homology
Amino Acid Sequence
Databases, Factual
Evolution, Molecular
Molecular Sequence Data
Multigene Family
Sequence Alignment
Sequence Homology, Amino Acid
Transcription Factors
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Du, H, Liang, Z, Zhao, S, Nan, M.-G, Tran, L.-S.P, Lu, K, Huang, Y.-B, Li, J.-N (2015). The evolutionary history of R2R3-myb proteins across 50 eukaryotes: New insights into subfamily classification and expansion. Scientific Reports 5 : 11037. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: R2R3-MYB proteins (2R-MYBs) are one of the main transcription factor families in higher plants. Since the evolutionary history of this gene family across the eukaryotic kingdom remains unknown, we performed a comparative analysis of 2R-MYBs from 50 major eukaryotic lineages, with particular emphasis on land plants. A total of 1548 candidates were identified among diverse taxonomic groups, which allowed for an updated classification of 73 highly conserved subfamilies, including many newly identified subfamilies. Our results revealed that the protein architectures, intron patterns, and sequence characteristics were remarkably conserved in each subfamily. At least four subfamilies were derived from early land plants, 10 evolved from spermatophytes, and 19 from angiosperms, demonstrating the diversity and preferential expansion of this gene family in land plants. Moreover, we determined that their remarkable expansion was mainly attributed to whole genome and segmental duplication, where duplicates were preferentially retained within certain subfamilies that shared three homologous intron patterns (a, b, and c) even though up to 12 types of patterns existed. Through our integrated distributions, sequence characteristics, and phylogenetic tree analyses, we confirm that 2R-MYBs are old and postulate that 3R-MYBs may be evolutionarily derived from 2R-MYBs via intragenic domain duplication.
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/srep11037
Rights: Attribution 4.0 International
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