Please use this identifier to cite or link to this item: https://doi.org/10.1038/cddis.2015.179
Title: Multiple sclerosis: Getting personal with induced pluripotent stem cells
Authors: Di Ruscio, A
Patti, F
Welner, R.S
Tenen, D.G 
Amabile, G
Keywords: epigenetics
genetic variability
genetics
human
medical research
multiple sclerosis
nonhuman
nuclear reprogramming
phenotype
pluripotent stem cell
priority journal
Review
biological therapy
cell differentiation
cell lineage
genetics
induced pluripotent stem cell
multiple sclerosis
personalized medicine
Cell Differentiation
Cell Lineage
Cell- and Tissue-Based Therapy
Humans
Induced Pluripotent Stem Cells
Multiple Sclerosis
Precision Medicine
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Di Ruscio, A, Patti, F, Welner, R.S, Tenen, D.G, Amabile, G (2015). Multiple sclerosis: Getting personal with induced pluripotent stem cells. Cell Death and Disease 6 (7) : e1806. ScholarBank@NUS Repository. https://doi.org/10.1038/cddis.2015.179
Rights: Attribution 4.0 International
Abstract: Human induced pluripotent stem (iPS) cells can be derived from lineage-restricted cells and represent an important tool to develop novel patient-specific cell therapies and research models for inherited and acquired diseases. Recently, patient-derived iPS cells, containing donor genetic background, have offered a breakthrough approach to study human genetics of neurodegenerative diseases. By offering an unlimited source of patient-specific disease-relevant cells, iPS cells hold great promise for understanding disease mechanisms, identifying molecular targets and developing phenotypic screens for drug discovery. This review will discuss the potential impact of using iPS cell-derived models in multiple sclerosis (MS) research and highlight some of the current challenges and prospective for generating novel therapeutic treatments for MS patients. © 2015 Macmillan Publishers Limited All rights reserved.
Source Title: Cell Death and Disease
URI: https://scholarbank.nus.edu.sg/handle/10635/180457
ISSN: 2041-4889
DOI: 10.1038/cddis.2015.179
Rights: Attribution 4.0 International
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