Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep17345
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dc.titleExploring molecular variation in Schistosoma japonicum in China
dc.contributor.authorYoung, N.D
dc.contributor.authorChan, K.-G
dc.contributor.authorKorhonen, P.K
dc.contributor.authorMin Chong, T
dc.contributor.authorEe, R
dc.contributor.authorMohandas, N
dc.contributor.authorKoehler, A.V
dc.contributor.authorLim, Y.-L
dc.contributor.authorHofmann, A
dc.contributor.authorJex, A.R
dc.contributor.authorQian, B
dc.contributor.authorChilton, N.B
dc.contributor.authorGobert, G.N
dc.contributor.authorMcManus, D.P
dc.contributor.authorTan, P
dc.contributor.authorWebster, B.L
dc.contributor.authorRollinson, D
dc.contributor.authorGasser, R.B
dc.date.accessioned2020-10-26T08:50:51Z
dc.date.available2020-10-26T08:50:51Z
dc.date.issued2015
dc.identifier.citationYoung, N.D, Chan, K.-G, Korhonen, P.K, Min Chong, T, Ee, R, Mohandas, N, Koehler, A.V, Lim, Y.-L, Hofmann, A, Jex, A.R, Qian, B, Chilton, N.B, Gobert, G.N, McManus, D.P, Tan, P, Webster, B.L, Rollinson, D, Gasser, R.B (2015). Exploring molecular variation in Schistosoma japonicum in China. Scientific Reports 5 : 17345. ScholarBank@NUS Repository. https://doi.org/10.1038/srep17345
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180408
dc.description.abstractSchistosomiasis is a neglected tropical disease that affects more than 200 million people worldwide. The main disease-causing agents, Schistosoma japonicum, S. mansoni and S. haematobium, are blood flukes that have complex life cycles involving a snail intermediate host. In Asia, S. japonicum causes hepatointestinal disease (schistosomiasis japonica) and is challenging to control due to a broad distribution of its snail hosts and range of animal reservoir hosts. In China, extensive efforts have been underway to control this parasite, but genetic variability in S. japonicum populations could represent an obstacle to eliminating schistosomiasis japonica. Although a draft genome sequence is available for S. japonicum, there has been no previous study of molecular variation in this parasite on a genome-wide scale. In this study, we conducted the first deep genomic exploration of seven S. japonicum populations from mainland China, constructed phylogenies using mitochondrial and nuclear genomic data sets, and established considerable variation between some of the populations in genes inferred to be linked to key cellular processes and/or pathogen-host interactions. Based on the findings from this study, we propose that verifying intraspecific conservation in vaccine or drug target candidates is an important first step toward developing effective vaccines and chemotherapies against schistosomiasis.
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectanimal
dc.subjectChina
dc.subjectfemale
dc.subjectgenetic variation
dc.subjectgenetics
dc.subjectgenome
dc.subjectgenome-wide association study
dc.subjecthuman
dc.subjectmale
dc.subjectSchistosoma japonicum
dc.subjectschistosomiasis japonica
dc.subjectAnimals
dc.subjectChina
dc.subjectFemale
dc.subjectGenetic Variation
dc.subjectGenome, Helminth
dc.subjectGenome-Wide Association Study
dc.subjectHumans
dc.subjectMale
dc.subjectSchistosoma japonicum
dc.subjectSchistosomiasis japonica
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/srep17345
dc.description.sourcetitleScientific Reports
dc.description.volume5
dc.description.page17345
dc.published.statepublished
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