Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.03180
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dc.titleCD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection
dc.contributor.authorLinterman, M.A
dc.contributor.authorDenton, A.E
dc.contributor.authorDivekar, D.P
dc.contributor.authorZvetkova, I
dc.contributor.authorKane, L
dc.contributor.authorFerreira, C
dc.contributor.authorVeldhoen, M
dc.contributor.authorClare, S
dc.contributor.authorDougan, G
dc.contributor.authorEspéli, M
dc.contributor.authorSmith, K.G.C
dc.date.accessioned2020-10-26T08:33:54Z
dc.date.available2020-10-26T08:33:54Z
dc.date.issued2014
dc.identifier.citationLinterman, M.A, Denton, A.E, Divekar, D.P, Zvetkova, I, Kane, L, Ferreira, C, Veldhoen, M, Clare, S, Dougan, G, Espéli, M, Smith, K.G.C (2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. eLife 3 (41913) : Jan-21. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03180
dc.identifier.issn2050084X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180376
dc.description.abstractThe co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming, we generated a strain of mice where CD28 is removed from CD4+ T cells after priming. We show that continued CD28 expression is important for effector CD4+ T cells following infection; maintained CD28 is required for the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicular helper cells during viral infection. Persistent CD28 is also required for clearance of the bacterium Citrobacter rodentium from the gastrointestinal tract. Together, this study demonstrates that CD28 persistence is required for helper T cell polarization in response to infection, describing a novel function for CD28 that is distinct from its role in T cell priming. © Linterman et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectCD134 antigen
dc.subjectCD28 antigen
dc.subjectcre recombinase
dc.subjectforkhead transcription factor
dc.subjectFoxp3 protein, mouse
dc.subjectintegrase
dc.subjectligand
dc.subjectTnfrsf4 protein, mouse
dc.subjectanimal
dc.subjectcell differentiation
dc.subjectcell proliferation
dc.subjectcellular immunity
dc.subjectCitrobacter rodentium
dc.subjectcross presentation
dc.subjectEnterobacteriaceae infection
dc.subjecthelper cell
dc.subjectimmunity
dc.subjectimmunology
dc.subjectInfluenza A virus
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmouse
dc.subjectorthomyxovirus infection
dc.subjectphysiology
dc.subjectsignal transduction
dc.subjectAnimals
dc.subjectAntigens, CD28
dc.subjectCell Differentiation
dc.subjectCell Proliferation
dc.subjectCitrobacter rodentium
dc.subjectCross-Priming
dc.subjectEnterobacteriaceae Infections
dc.subjectForkhead Transcription Factors
dc.subjectImmunity
dc.subjectImmunity, Cellular
dc.subjectInfluenza A virus
dc.subjectIntegrases
dc.subjectLigands
dc.subjectMice
dc.subjectOrthomyxoviridae Infections
dc.subjectReceptors, OX40
dc.subjectSignal Transduction
dc.subjectT-Lymphocytes, Helper-Inducer
dc.typeArticle
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.7554/eLife.03180
dc.description.sourcetitleeLife
dc.description.volume3
dc.description.issue41913
dc.description.pageJan-21
dc.published.statePublished
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