Please use this identifier to cite or link to this item: https://doi.org/10.1155/2016/8597085
Title: The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population
Authors: Ding, X.-Y
Yuan, H.-Z
Gu, R
Gaao, Y.-F
Liu, X.-G 
Gao, Y
Keywords: C reactive protein
peroxisome proliferator activated receptor delta
adult
allele
amino acid substitution
Article
Chinese
female
gene frequency
gene interaction
gene locus
genetic association
genotype
human
male
priority journal
single nucleotide polymorphism
Issue Date: 2016
Citation: Ding, X.-Y, Yuan, H.-Z, Gu, R, Gaao, Y.-F, Liu, X.-G, Gao, Y (2016). The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population. International Journal of Endocrinology 2016 : 8597085. ScholarBank@NUS Repository. https://doi.org/10.1155/2016/8597085
Rights: Attribution 4.0 International
Abstract: Aims. To examine the association between 4 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors δ (PPARδ) polymorphisms and C-reactive protein (CRP) level and additional gene-gene interaction. Methods. Line regression analysis was performed to verify polymorphism association between SNP and CRP levels. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the interaction. Results. A total of 1028 subjects (538 men, 490 women) were selected. The carriers of the C allele (TC or CC) of rs2016520 were associated with a significant decreased level of CRP, regression coefficients was -0.338, and standard error was 0.104 (p = 0.001). The carriers of the G allele (CG or GG) of rs9794 were also significantly associated with decreased level of CRP, regression coefficients was -0.219, and standard error was 0.114 (p = 0.012). We also found a potential gene-gene interaction between rs2016520 and rs9794. Subjects with rs2016520-TC or CC, rs9794-CG or GG genotypes have lowest CRP level, difference (95% CI) = -0.50 (-0.69 to -0.21) (p < 0.001), compared to subjects with rs2016520-TT and rs9794-CC genotypes. Conclusions. rs2016520 and rs9794 minor allele of PPARδ and combined effect between the two SNP were associated with decreased CRP level. © 2016 Xiao-Ying Ding et al.
Source Title: International Journal of Endocrinology
URI: https://scholarbank.nus.edu.sg/handle/10635/179981
ISSN: 16878337
DOI: 10.1155/2016/8597085
Rights: Attribution 4.0 International
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