Please use this identifier to cite or link to this item: https://doi.org/10.7448/IAS.19.1.20965
Title: Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database
Authors: Ahn, J.Y
Boettiger, D
Kiertiburanakul, S
Keywords: adult
Article
Asia
data base
female
human
Human immunodeficiency virus infected patient
Human immunodeficiency virus infection
major clinical study
male
men who have sex with men
multicenter study
priority journal
seroconversion
syphilis
adolescent
complication
HIV Infections
incidence
male homosexuality
middle aged
risk factor
syphilis
Adolescent
Adult
Asia
Female
HIV Infections
Homosexuality, Male
Humans
Incidence
Male
Middle Aged
Risk Factors
Seroconversion
Syphilis
Issue Date: 2016
Citation: Ahn, J.Y, Boettiger, D, Kiertiburanakul, S (2016). Incidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Database. Journal of the International AIDS Society 19 (1) : 20965. ScholarBank@NUS Repository. https://doi.org/10.7448/IAS.19.1.20965
Rights: Attribution 4.0 International
Abstract: Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population. Copyright © 2016 Ahn JY et al; licensee International AIDS Society.
Source Title: Journal of the International AIDS Society
URI: https://scholarbank.nus.edu.sg/handle/10635/179948
ISSN: 17582652
DOI: 10.7448/IAS.19.1.20965
Rights: Attribution 4.0 International
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