Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep37126
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dc.titleAllostasis in health and food addiction
dc.contributor.authorDe Ridder, D
dc.contributor.authorManning, P
dc.contributor.authorLeong, S.L
dc.contributor.authorRoss, S
dc.contributor.authorVanneste, S
dc.date.accessioned2020-10-26T03:06:05Z
dc.date.available2020-10-26T03:06:05Z
dc.date.issued2016
dc.identifier.citationDe Ridder, D, Manning, P, Leong, S.L, Ross, S, Vanneste, S (2016). Allostasis in health and food addiction. Scientific Reports 6 : 37126. ScholarBank@NUS Repository. https://doi.org/10.1038/srep37126
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179785
dc.description.abstractHomeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group. Correlation analyses were performed on behavioral data, and correlation, comparative and conjunction analyses were performed to extract electrophysiological relationships between pleasure, salience, allostasis and withdrawal. Pleasure/liking seems to be the phenomenological expression that enough salient stimuli are obtained, and withdrawal can be seen as a motivational incentive because due to allostatic reference resetting, more stimuli are required. In addition, in contrast to non-addiction, a pathological, non-adaptive salience attached to food results in withdrawal mediated through persistent allostatic reference resetting. © The Author(s) 2016.
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectadult
dc.subjectallostasis
dc.subjectbrain
dc.subjectelectroencephalogram
dc.subjectelectroencephalography
dc.subjectfemale
dc.subjectfood addiction
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectpathophysiology
dc.subjectpleasure
dc.subjectwithdrawal syndrome
dc.subjectAdult
dc.subjectAllostasis
dc.subjectBrain
dc.subjectBrain Waves
dc.subjectElectroencephalography
dc.subjectFemale
dc.subjectFood Addiction
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPleasure
dc.subjectSubstance Withdrawal Syndrome
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1038/srep37126
dc.description.sourcetitleScientific Reports
dc.description.volume6
dc.description.page37126
dc.published.statepublished
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