Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.18112
Title: p53 upregulates PLC?-IP3-Ca 2+ pathway and inhibits autophagy through its target gene Rap2B
Authors: Di, J
Tang, J
Qian, H
Franklin, D.A
Deisenroth, C
Itahana, Y 
Zheng, J
Zhang, Y
Keywords: calcium
dactinomycin
inositol trisphosphate
peptides and proteins
phosphodiesterase
phospholipase C epsilon
protein LC3
protein p53
unclassified drug
animal cell
Article
autophagy
binding site
calcium cell level
controlled study
embryo
gene
gene expression
gene locus
gene targeting
genetic transcription
microarray analysis
mouse
nonhuman
protein binding
Rap2B gene
signal transduction
starvation
ultraviolet radiation
upregulation
wild type
Issue Date: 2017
Publisher: Impact Journals LLC
Citation: Di, J, Tang, J, Qian, H, Franklin, D.A, Deisenroth, C, Itahana, Y, Zheng, J, Zhang, Y (2017). p53 upregulates PLC?-IP3-Ca 2+ pathway and inhibits autophagy through its target gene Rap2B. Oncotarget 8 (39) : 64657-64669. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.18112
Rights: Attribution 4.0 International
Abstract: The tumor suppressor p53 plays a pivotal role in numerous cellular responses as it regulates cell proliferation, metabolism, cellular growth, and autophagy. In order to identify novel p53 target genes, we utilized an unbiased microarray approach and identified Rap2B as a robust candidate, which belongs to the Ras-related GTPbinding protein superfamily and exhibits increased expression in various human cancers. We demonstrated that p53 increases the intracellular IP3 and Ca 2+ levels and decreases the LC3 protein levels through its target gene Rap2B, suggesting that p53 can inhibit the autophagic response triggered by starvation via upregulation of the Rap2B-PLC?-IP3-Ca 2+ pathway. As a confirmed target gene of p53, we believe that further investigating potential functions of Rap2B in autophagy and tumorigenesis will provide a novel strategy for cancer therapy. © Di et al.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/179754
ISSN: 1949-2553
DOI: 10.18632/oncotarget.18112
Rights: Attribution 4.0 International
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