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https://doi.org/10.1038/srep41386
Title: | Systemic, ocular and genetic risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Singaporeans | Authors: | Cheung, C.M.G Laude, A Yeo, I Tan, S.-P Fan, Q Mathur, R Lee, S.Y Chan, C.M Tan, G Lim, T.H Cheng, C.-Y Wong, T.Y |
Keywords: | aged case control study complication demography eye female genetic predisposition genetics human macular degeneration male middle aged pathology risk factor Singapore subretinal neovascularization Aged Case-Control Studies Choroidal Neovascularization Demography Eye Female Genetic Predisposition to Disease Humans Macular Degeneration Male Middle Aged Risk Factors Singapore |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Citation: | Cheung, C.M.G, Laude, A, Yeo, I, Tan, S.-P, Fan, Q, Mathur, R, Lee, S.Y, Chan, C.M, Tan, G, Lim, T.H, Cheng, C.-Y, Wong, T.Y (2017). Systemic, ocular and genetic risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Singaporeans. Scientific Reports 7 : 41386. ScholarBank@NUS Repository. https://doi.org/10.1038/srep41386 | Rights: | Attribution 4.0 International | Abstract: | To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and polypoidal choroidal vasculoapthy (PCV) subtypes. We recruited 456 cases and 1,824 controls matched for age, gender and ethnicity. Data on systemic and ocular risk factors were collected on questionnaires. In a subgroup of subjects, we included genetic data on four AMD-associated single nucleotide polymorphisms (SNPs). Risk factors for nAMD and subtypes were analyzed. Systemic risk factors for nAMD included older age, male gender, higher BMI and higher HDL-cholesterol. Ocular risk factors included pseudophakic and shorter axial length. Risk factors common to both typical AMD and PCV subtypes included age, BMI and HDL-cholesterol. Shorter axial length was only associated with PCV, while male gender and pseudophakia were only associated with typical AMD. In the subgroup with genotype data, ARMS2 rs10490924 and CFH rs800292 were associated with nAMD. None of the risk factors were significantly different between PCV and typical AMD. Systemic, ocular and genetic risk factors were largely similar for typical AMD and PCV subtypes in this Asian population based in Singapore. © The Author(s) 2017. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/179740 | ISSN: | 2045-2322 | DOI: | 10.1038/srep41386 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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