Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep41386
Title: Systemic, ocular and genetic risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Singaporeans
Authors: Cheung, C.M.G 
Laude, A
Yeo, I 
Tan, S.-P
Fan, Q 
Mathur, R
Lee, S.Y 
Chan, C.M 
Tan, G
Lim, T.H
Cheng, C.-Y 
Wong, T.Y 
Keywords: aged
case control study
complication
demography
eye
female
genetic predisposition
genetics
human
macular degeneration
male
middle aged
pathology
risk factor
Singapore
subretinal neovascularization
Aged
Case-Control Studies
Choroidal Neovascularization
Demography
Eye
Female
Genetic Predisposition to Disease
Humans
Macular Degeneration
Male
Middle Aged
Risk Factors
Singapore
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Cheung, C.M.G, Laude, A, Yeo, I, Tan, S.-P, Fan, Q, Mathur, R, Lee, S.Y, Chan, C.M, Tan, G, Lim, T.H, Cheng, C.-Y, Wong, T.Y (2017). Systemic, ocular and genetic risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Singaporeans. Scientific Reports 7 : 41386. ScholarBank@NUS Repository. https://doi.org/10.1038/srep41386
Rights: Attribution 4.0 International
Abstract: To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and polypoidal choroidal vasculoapthy (PCV) subtypes. We recruited 456 cases and 1,824 controls matched for age, gender and ethnicity. Data on systemic and ocular risk factors were collected on questionnaires. In a subgroup of subjects, we included genetic data on four AMD-associated single nucleotide polymorphisms (SNPs). Risk factors for nAMD and subtypes were analyzed. Systemic risk factors for nAMD included older age, male gender, higher BMI and higher HDL-cholesterol. Ocular risk factors included pseudophakic and shorter axial length. Risk factors common to both typical AMD and PCV subtypes included age, BMI and HDL-cholesterol. Shorter axial length was only associated with PCV, while male gender and pseudophakia were only associated with typical AMD. In the subgroup with genotype data, ARMS2 rs10490924 and CFH rs800292 were associated with nAMD. None of the risk factors were significantly different between PCV and typical AMD. Systemic, ocular and genetic risk factors were largely similar for typical AMD and PCV subtypes in this Asian population based in Singapore. © The Author(s) 2017.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/179740
ISSN: 2045-2322
DOI: 10.1038/srep41386
Rights: Attribution 4.0 International
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