Please use this identifier to cite or link to this item: https://doi.org/10.1111/nph.13701
DC FieldValue
dc.titleA novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system
dc.contributor.authorLin, B
dc.contributor.authorZhuo, K
dc.contributor.authorChen, S
dc.contributor.authorHu, L
dc.contributor.authorSun, L
dc.contributor.authorWang, X
dc.contributor.authorZhang, L.-H
dc.contributor.authorLiao, J
dc.date.accessioned2020-10-23T08:01:09Z
dc.date.available2020-10-23T08:01:09Z
dc.date.issued2016
dc.identifier.citationLin, B, Zhuo, K, Chen, S, Hu, L, Sun, L, Wang, X, Zhang, L.-H, Liao, J (2016). A novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system. New Phytologist 209 (3) : 1159-1173. ScholarBank@NUS Repository. https://doi.org/10.1111/nph.13701
dc.identifier.issn0028-646X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179604
dc.description.abstractEvidence is emerging that plant-parasitic nematodes can secrete effectors to interfere with the host immune response, but it remains unknown how these effectors can conquer host immune responses. Here, we depict a novel effector, MjTTL5, that could suppress plant immune response. Immunolocalization and transcriptional analyses showed that MjTTL5 is expressed specifically within the subventral gland of Meloidogyne javanica and up-regulated in the early parasitic stage of the nematode. Transgenic Arabidopsis lines expressing MjTTL5 were significantly more susceptible to M. javanica infection than wild-type plants, and vice versa, in planta silencing of MjTTL5 substantially increased plant resistance to M. javanica. Yeast two-hybrid, coimmunoprecipitation and bimolecular fluorescent complementation assays showed that MjTTL5 interacts specifically with Arabidopsis ferredoxin : thioredoxin reductase catalytic subunit (AtFTRc), a key component of host antioxidant system. The expression of AtFTRc is induced by the infection of M. javanica. Interaction between AtFTRc and MjTTL could drastically increase host reactive oxygen species-scavenging activity, and result in suppression of plant basal defenses and attenuation of host resistance to the nematode infection. Our results demonstrate that the host ferredoxin : thioredoxin system can be exploited cunningly by M. javanica, revealing a novel mechanism utilized by plant-parasitic nematodes to subjugate plant innate immunity and thereby promoting parasitism. © 2016 New Phytologist Trust.
dc.publisherBlackwell Publishing Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectangiosperm
dc.subjectimmune response
dc.subjectimmunity
dc.subjectnematode
dc.subjectpathogen
dc.subjectprotein
dc.subjectArabidopsis
dc.subjectArabidopsis thaliana
dc.subjectMeloidogyne javanica
dc.subjectNematoda
dc.subjectArabidopsis protein
dc.subjecthelminth protein
dc.subjecthydrogen peroxide
dc.subjectpathogen associated molecular pattern
dc.subjectprotein binding
dc.subjectreactive oxygen metabolite
dc.subjectscavenger
dc.subjectanimal
dc.subjectArabidopsis
dc.subjectBayes theorem
dc.subjectchemistry
dc.subjectcomputer simulation
dc.subjectdisease resistance
dc.subjectgene
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjecthost parasite interaction
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectmolecular cloning
dc.subjectmutation
dc.subjectparasite
dc.subjectparasitology
dc.subjectphylogeny
dc.subjectphysiology
dc.subjectplant disease
dc.subjectplant gene
dc.subjectplant immunity
dc.subjectprotein domain
dc.subjectRNA interference
dc.subjectTylenchoidea
dc.subjectupregulation
dc.subjectAnimals
dc.subjectArabidopsis
dc.subjectArabidopsis Proteins
dc.subjectBayes Theorem
dc.subjectCloning, Molecular
dc.subjectComputer Simulation
dc.subjectDisease Resistance
dc.subjectFree Radical Scavengers
dc.subjectGene Expression Regulation, Plant
dc.subjectGenes, Helminth
dc.subjectGenes, Plant
dc.subjectHelminth Proteins
dc.subjectHost-Parasite Interactions
dc.subjectHydrogen Peroxide
dc.subjectMutation
dc.subjectParasites
dc.subjectPathogen-Associated Molecular Pattern Molecules
dc.subjectPhylogeny
dc.subjectPlant Diseases
dc.subjectPlant Immunity
dc.subjectProtein Binding
dc.subjectProtein Domains
dc.subjectReactive Oxygen Species
dc.subjectRNA Interference
dc.subjectTylenchoidea
dc.subjectUp-Regulation
dc.typeArticle
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1111/nph.13701
dc.description.sourcetitleNew Phytologist
dc.description.volume209
dc.description.issue3
dc.description.page1159-1173
dc.published.statePublished
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