Please use this identifier to cite or link to this item: https://doi.org/10.1111/nph.13701
Title: A novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system
Authors: Lin, B
Zhuo, K
Chen, S
Hu, L
Sun, L
Wang, X
Zhang, L.-H 
Liao, J
Keywords: angiosperm
immune response
immunity
nematode
pathogen
protein
Arabidopsis
Arabidopsis thaliana
Meloidogyne javanica
Nematoda
Arabidopsis protein
helminth protein
hydrogen peroxide
pathogen associated molecular pattern
protein binding
reactive oxygen metabolite
scavenger
animal
Arabidopsis
Bayes theorem
chemistry
computer simulation
disease resistance
gene
gene expression regulation
genetics
host parasite interaction
immunology
metabolism
molecular cloning
mutation
parasite
parasitology
phylogeny
physiology
plant disease
plant gene
plant immunity
protein domain
RNA interference
Tylenchoidea
upregulation
Animals
Arabidopsis
Arabidopsis Proteins
Bayes Theorem
Cloning, Molecular
Computer Simulation
Disease Resistance
Free Radical Scavengers
Gene Expression Regulation, Plant
Genes, Helminth
Genes, Plant
Helminth Proteins
Host-Parasite Interactions
Hydrogen Peroxide
Mutation
Parasites
Pathogen-Associated Molecular Pattern Molecules
Phylogeny
Plant Diseases
Plant Immunity
Protein Binding
Protein Domains
Reactive Oxygen Species
RNA Interference
Tylenchoidea
Up-Regulation
Issue Date: 2016
Publisher: Blackwell Publishing Ltd
Citation: Lin, B, Zhuo, K, Chen, S, Hu, L, Sun, L, Wang, X, Zhang, L.-H, Liao, J (2016). A novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system. New Phytologist 209 (3) : 1159-1173. ScholarBank@NUS Repository. https://doi.org/10.1111/nph.13701
Rights: Attribution 4.0 International
Abstract: Evidence is emerging that plant-parasitic nematodes can secrete effectors to interfere with the host immune response, but it remains unknown how these effectors can conquer host immune responses. Here, we depict a novel effector, MjTTL5, that could suppress plant immune response. Immunolocalization and transcriptional analyses showed that MjTTL5 is expressed specifically within the subventral gland of Meloidogyne javanica and up-regulated in the early parasitic stage of the nematode. Transgenic Arabidopsis lines expressing MjTTL5 were significantly more susceptible to M. javanica infection than wild-type plants, and vice versa, in planta silencing of MjTTL5 substantially increased plant resistance to M. javanica. Yeast two-hybrid, coimmunoprecipitation and bimolecular fluorescent complementation assays showed that MjTTL5 interacts specifically with Arabidopsis ferredoxin : thioredoxin reductase catalytic subunit (AtFTRc), a key component of host antioxidant system. The expression of AtFTRc is induced by the infection of M. javanica. Interaction between AtFTRc and MjTTL could drastically increase host reactive oxygen species-scavenging activity, and result in suppression of plant basal defenses and attenuation of host resistance to the nematode infection. Our results demonstrate that the host ferredoxin : thioredoxin system can be exploited cunningly by M. javanica, revealing a novel mechanism utilized by plant-parasitic nematodes to subjugate plant innate immunity and thereby promoting parasitism. © 2016 New Phytologist Trust.
Source Title: New Phytologist
URI: https://scholarbank.nus.edu.sg/handle/10635/179604
ISSN: 0028-646X
DOI: 10.1111/nph.13701
Rights: Attribution 4.0 International
Appears in Collections:Elements
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