Please use this identifier to cite or link to this item: https://doi.org/10.1042/BSR20150180
Title: Diagnostic technologies for circulating tumour cells and exosomes
Authors: Shao, H 
Chung, J
Issadore, D
Keywords: circulating tumor cell
exosome
animal
human
metabolism
Neoplasms
pathology
tumor embolism
tumor marker
Animals
Biomarkers, Tumor
Exosomes
Humans
Neoplasms
Neoplastic Cells, Circulating
Issue Date: 2016
Publisher: Portland Press Ltd
Citation: Shao, H, Chung, J, Issadore, D (2016). Diagnostic technologies for circulating tumour cells and exosomes. Bioscience Reports 36 (1) : e00292. ScholarBank@NUS Repository. https://doi.org/10.1042/BSR20150180
Rights: Attribution 4.0 International
Abstract: Circulating tumour cells (CTCs) and exosomes are promising circulating biomarkers. They exist in easily accessible blood and carry large diversity of molecular information. As such, they can be easily and repeatedly obtained for minimally invasive cancer diagnosis and monitoring. Because of their intrinsic differences in counts, size and molecular contents, CTCs and exosomes pose unique sets of technical challenges for clinical translation - CTCs are rare whereas exosomes are small. Novel technologies are underway to overcome these specific challenges to fully harness the clinical potential of these circulating biomarkers. Herein, we will overview the characteristics of CTCs and exosomes as valuable circulating biomarkers and their associated technical challenges for clinical adaptation. Specifically, we will describe emerging technologies that have been developed to address these technical obstacles and the unique clinical opportunities enabled by technological innovations. © 2016 Authors.
Source Title: Bioscience Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/179598
ISSN: 0144-8463
DOI: 10.1042/BSR20150180
Rights: Attribution 4.0 International
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