Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12916-017-0917-2
Title: Gestational hypertensive disorders and retinal microvasculature: The Generation R Study
Authors: Benschop, L
Schalekamp-Timmermans, S
Roeters van Lennep, J.E
Jaddoe, V.W.V
Wong, T.Y 
Cheung, C.Y
Steegers, E.A.P
Ikram, M.K
Keywords: adult
artery diameter
Article
camera
cohort analysis
controlled study
digital retinal camera
female
human
major clinical study
maternal hypertension
mean arterial pressure
preeclampsia
prospective study
retina blood vessel
retinal arteriole
vein diameter
venule
blood pressure
microvasculature
pathophysiology
preeclampsia
pregnancy
Adult
Blood Pressure
Female
Humans
Hypertension, Pregnancy-Induced
Microvessels
Pre-Eclampsia
Pregnancy
Prospective Studies
Retinal Vessels
Issue Date: 2017
Citation: Benschop, L, Schalekamp-Timmermans, S, Roeters van Lennep, J.E, Jaddoe, V.W.V, Wong, T.Y, Cheung, C.Y, Steegers, E.A.P, Ikram, M.K (2017). Gestational hypertensive disorders and retinal microvasculature: The Generation R Study. BMC Medicine 15 (1) : 153. ScholarBank@NUS Repository. https://doi.org/10.1186/s12916-017-0917-2
Rights: Attribution 4.0 International
Abstract: Background: Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy. Methods: This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6.2 years after the index pregnancy (90% range 5.7-7.4 years), we examined 3391 women with available information on pre-eclampsia, gestational hypertension, and retinal vascular calibers. Retinal arteriolar and venular calibers were measured in the left eye from digitized retinal photographs. Results: Women with pre-eclampsia had smaller retinal arteriolar calibers 6 years after pregnancy than women with a normotensive pregnancy (adjusted difference: -0.40 standard deviation score [SDS]; 95% confidence interval [CI]: -0.62, -0.19). For women with previous gestational hypertension, similar trends were observed (-0.20 SDS; 95% CI: -0.34, -0.05). With respect to retinal venular calibers, we did not observe consistent trends for women with previous pre-eclampsia. However, in women with previous gestational hypertension, we observed larger venular calibers (0.22 SDS; 95% CI: 0.07-0.36) than in women with a previous normotensive pregnancy. The association of gestational hypertensive disorders with retinal vessel calibers was mediated through mean arterial pressure at the time of retinal imaging. Conclusions: Compared to women with a previous normotensive pregnancy, women with pre-eclampsia and gestational hypertension show an altered status of the microvasculature 6 years after the index pregnancy. This is reflected by smaller retinal arteriolar calibers and wider retinal venular calibers. These microvascular changes may possibly contribute to the development of cardiovascular disease in later life. @ 2017 The Author(s).
Source Title: BMC Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/179466
ISSN: 17417015
DOI: 10.1186/s12916-017-0917-2
Rights: Attribution 4.0 International
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