Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.03180
Title: CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection
Authors: Linterman, M.A
Denton, A.E
Divekar, D.P
Zvetkova, I
Kane, L
Ferreira, C
Veldhoen, M
Clare, S
Dougan, G
Espéli, M
Smith, K.G.C 
Keywords: CD134 antigen
CD28 antigen
cre recombinase
forkhead transcription factor
Foxp3 protein, mouse
integrase
ligand
Tnfrsf4 protein, mouse
animal
cell differentiation
cell proliferation
cellular immunity
Citrobacter rodentium
cross presentation
Enterobacteriaceae infection
helper cell
immunity
immunology
Influenza A virus
metabolism
microbiology
mouse
orthomyxovirus infection
physiology
signal transduction
Animals
Antigens, CD28
Cell Differentiation
Cell Proliferation
Citrobacter rodentium
Cross-Priming
Enterobacteriaceae Infections
Forkhead Transcription Factors
Immunity
Immunity, Cellular
Influenza A virus
Integrases
Ligands
Mice
Orthomyxoviridae Infections
Receptors, OX40
Signal Transduction
T-Lymphocytes, Helper-Inducer
Issue Date: 2014
Citation: Linterman, M.A, Denton, A.E, Divekar, D.P, Zvetkova, I, Kane, L, Ferreira, C, Veldhoen, M, Clare, S, Dougan, G, Espéli, M, Smith, K.G.C (2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. eLife 3 (41913) : Jan-21. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03180
Rights: Attribution 4.0 International
Abstract: The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming, we generated a strain of mice where CD28 is removed from CD4+ T cells after priming. We show that continued CD28 expression is important for effector CD4+ T cells following infection; maintained CD28 is required for the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicular helper cells during viral infection. Persistent CD28 is also required for clearance of the bacterium Citrobacter rodentium from the gastrointestinal tract. Together, this study demonstrates that CD28 persistence is required for helper T cell polarization in response to infection, describing a novel function for CD28 that is distinct from its role in T cell priming. © Linterman et al.
Source Title: eLife
URI: https://scholarbank.nus.edu.sg/handle/10635/179410
ISSN: 2050084X
DOI: 10.7554/eLife.03180
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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