Please use this identifier to cite or link to this item: https://doi.org/10.1155/2017/4719403
Title: Soluble urokinase plasminogen activator receptor and the risk of coronary artery disease in young Chinese patients
Authors: Huang, Y 
Zhou, H
Wu, Y
Yang, Y
Li, W
Lu, J
Hu, Y
Keywords: C reactive protein
urokinase receptor
biological marker
urokinase receptor
adult
aged
anxiety
Article
body mass
cardiac patient
cardiovascular risk
Caucasian
Chinese
comparative study
controlled study
coronary artery disease
depression
disease severity
dyslipidemia
enzyme linked immunosorbent assay
female
human
major clinical study
male
medical history
non ST segment elevation myocardial infarction
obesity
severe hepatic impairment
severe renal impairment
smoking
ST segment elevation myocardial infarction
unstable angina pectoris
age
blood
case control study
China
coronary artery disease
middle aged
onset age
pathology
sex factor
Adult
Age Factors
Age of Onset
Biomarkers
Case-Control Studies
China
Coronary Artery Disease
Female
Humans
Male
Middle Aged
Receptors, Urokinase Plasminogen Activator
Sex Factors
Issue Date: 2017
Publisher: Hindawi Limited
Citation: Huang, Y, Zhou, H, Wu, Y, Yang, Y, Li, W, Lu, J, Hu, Y (2017). Soluble urokinase plasminogen activator receptor and the risk of coronary artery disease in young Chinese patients. Disease Markers 2017 : 4719403. ScholarBank@NUS Repository. https://doi.org/10.1155/2017/4719403
Rights: Attribution 4.0 International
Abstract: Background. Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians. This study investigated the role of suPAR in young Chinese patients with CAD. Methods. The study involved a total of 196 consecutive young (age 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls. Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays. Results. Levels of suPAR were significantly correlated with age (r=0.20, P=0.04), smoking (r=0.33, P=0.008), body mass index (r=0.21, P=0.03), and high-sensitivity C-reactive protein (hs-CRP; r=0.31, P=0.01). Multivariate logistic regression analysis showed that male sex (odds ratio (OR) = 3.12; 95% confidence interval (CI) = 1.18-8.25, P=0.02), smoking (OR = 3.41, 95% CI = 1.55-7.50, P=0.002), triglyceride (OR = 1.89, 95% CI = 1.10-3.25, P=0.02), high-sensitivity C-reactive protein (OR = 1.24, 95% CI = 1.02-0.03, P=0.03), and suPAR (OR = 1.37, 95% CI = 1.09-1.72, P=0.007) were independently associated with CAD risk in young patients. Conclusions. SuPAR is a novel independent risk factor for CAD in young Chinese patients. Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed. © 2017 Yuli Huang et al.
Source Title: Disease Markers
URI: https://scholarbank.nus.edu.sg/handle/10635/179255
ISSN: 0278-0240
DOI: 10.1155/2017/4719403
Rights: Attribution 4.0 International
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