Please use this identifier to cite or link to this item: https://doi.org/10.1084/jem.20161382
Title: Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
Authors: Thomas, D.C
Clare, S
Sowerby, J.M
Pardo, M
Juss, J.K
Goulding, D.A
van der Weyden, L
Storisteanu, D
Prakash, A
Espéli, M
Flint, S
Lee, J.C
Hoenderdos, K
Kane, L
Harcourt, K
Mukhopadhyay, S
Umrania, Y
Antrobus, R
Nathan, J.A
Adams, D.J
Bateman, A
Choudhary, J.S
Lyons, P.A
Condliffe, A.M
Chilvers, E.R
Dougan, G
Smith, K.G.C 
Keywords: cytochrome b558
essential for reactive oxygen species
glycoprotein gp 91
interleukin 10
interleukin 12p70
interleukin 6
membrane protein
plant protein
protein p22
protein p40
protein p47
protein p67
proteome
Rac protein
reactive oxygen metabolite
reduced nicotinamide adenine dinucleotide phosphate oxidase
tumor necrosis factor
unclassified drug
Ycf4 protein
Cybb protein, mouse
cytochrome b
Eros protein, mouse
membrane protein
p22(phox) protein, mouse
reactive oxygen metabolite
reduced nicotinamide adenine dinucleotide phosphate oxidase
animal cell
animal experiment
animal model
animal tissue
Article
Citrobacter rodentium
citrobacter rodentium infection
comparative study
controlled study
Enterobacteriaceae infection
extracellular trap
female
host resistance
human
human cell
infection risk
innate immunity
macrophage
metastatic melanoma
mouse
neutrophil
nonhuman
normal human
orthology
phagocyte
photosynthesis
photosystem I
priority journal
protein expression
protein function
respiratory burst
Salmonella enterica serovar Typhimurium
tumor immunity
typhoid fever
animal
C57BL mouse
endoplasmic reticulum
HEK293 cell line
immunology
innate immunity
metabolism
phagocyte
phagocytosis
physiology
respiratory burst
Animals
Cytochrome b Group
Endoplasmic Reticulum
HEK293 Cells
Humans
Immunity, Innate
Macrophages
Membrane Glycoproteins
Membrane Proteins
Mice
Mice, Inbred C57BL
NADPH Oxidase
Neutrophils
Phagocytes
Phagocytosis
Reactive Oxygen Species
Respiratory Burst
Issue Date: 2017
Publisher: Rockefeller University Press
Citation: Thomas, D.C, Clare, S, Sowerby, J.M, Pardo, M, Juss, J.K, Goulding, D.A, van der Weyden, L, Storisteanu, D, Prakash, A, Espéli, M, Flint, S, Lee, J.C, Hoenderdos, K, Kane, L, Harcourt, K, Mukhopadhyay, S, Umrania, Y, Antrobus, R, Nathan, J.A, Adams, D.J, Bateman, A, Choudhary, J.S, Lyons, P.A, Condliffe, A.M, Chilvers, E.R, Dougan, G, Smith, K.G.C (2017). Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. Journal of Experimental Medicine 214 (4) : 1111-1128. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20161382
Rights: Attribution 4.0 International
Abstract: The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane- bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643, and show that it is essential for host defense via the phagocyte NAP D H oxidase. Eros is required for expression of the NADPH oxidase components, gp91phox and p22phox. Consequently, Eros-deficient mice quickly succumb to infection. Eros also contributes to the formation of neutrophil extracellular traps (NETS) and impacts on the immune response to melanoma metastases. Eros is an ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthetic photosystem 1 complex, itself also an NADPH oxio-reductase. We thus describe the key role of the previously uncharacterized protein Eros in host defense. © 2017 Thomas et al.
Source Title: Journal of Experimental Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/179211
ISSN: 0022-1007
DOI: 10.1084/jem.20161382
Rights: Attribution 4.0 International
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