Please use this identifier to cite or link to this item:
https://doi.org/10.1038/mp.2016.60
Title: | Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group | Authors: | Schmaal, L Hibar, D.P Sämann, P.G |
Keywords: | adolescent adult anterior cingulate Article brain cortex brain disease brain radiography brain size cohort analysis controlled study female gray matter human human tissue image analysis insula major clinical study major depression male multicenter study neuroanatomy neuroimaging nuclear magnetic resonance imaging onset age orbital cortex posterior cingulate primary motor cortex priority journal somatosensory cortex statistical analysis striate cortex superior frontal gyrus surface area temporal lobe brain cingulate gyrus diagnostic imaging frontal lobe major depression meta analysis pathology prefrontal cortex procedures psychology Adolescent Adult Brain Cerebral Cortex Depressive Disorder, Major Female Frontal Lobe Gray Matter Gyrus Cinguli Humans Magnetic Resonance Imaging Male Neuroimaging Prefrontal Cortex Temporal Lobe |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Citation: | Schmaal, L, Hibar, D.P, Sämann, P.G (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular Psychiatry 22 (6) : 900-909. ScholarBank@NUS Repository. https://doi.org/10.1038/mp.2016.60 | Rights: | Attribution 4.0 International | Abstract: | The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life. © 2017 Macmillan Publishers Limited, part of Springer Nature. | Source Title: | Molecular Psychiatry | URI: | https://scholarbank.nus.edu.sg/handle/10635/179203 | ISSN: | 13594184 | DOI: | 10.1038/mp.2016.60 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1038_mp_2016_60.pdf | 731.29 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License