Please use this identifier to cite or link to this item:
https://doi.org/10.3945/jn.117.252981
DC Field | Value | |
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dc.title | Lipid-based nutrient supplements during pregnancy and lactation did not affect human milk oligosaccharides and bioactive proteins in a randomized trial | |
dc.contributor.author | Jorgensen, J.M | |
dc.contributor.author | Arnold, C | |
dc.contributor.author | Ashorn, P | |
dc.contributor.author | Ashorn, U | |
dc.contributor.author | Chaima, D | |
dc.contributor.author | Cheung, Y.B | |
dc.contributor.author | Davis, J.C.C | |
dc.contributor.author | Fan, Y.-M | |
dc.contributor.author | Goonatilleke, E | |
dc.contributor.author | Kortekangas, E | |
dc.contributor.author | Kumwenda, C | |
dc.contributor.author | Lebrilla, C.B | |
dc.contributor.author | Maleta, K | |
dc.contributor.author | Totten, S.M | |
dc.contributor.author | Wu, L.D | |
dc.contributor.author | Dewey, K.G | |
dc.date.accessioned | 2020-10-22T07:36:04Z | |
dc.date.available | 2020-10-22T07:36:04Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Jorgensen, J.M, Arnold, C, Ashorn, P, Ashorn, U, Chaima, D, Cheung, Y.B, Davis, J.C.C, Fan, Y.-M, Goonatilleke, E, Kortekangas, E, Kumwenda, C, Lebrilla, C.B, Maleta, K, Totten, S.M, Wu, L.D, Dewey, K.G (2017). Lipid-based nutrient supplements during pregnancy and lactation did not affect human milk oligosaccharides and bioactive proteins in a randomized trial. Journal of Nutrition 147 (10) : 1867-1874. ScholarBank@NUS Repository. https://doi.org/10.3945/jn.117.252981 | |
dc.identifier.issn | 00223166 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/179087 | |
dc.description.abstract | Background: Human milk oligosaccharides (HMOs) and bioactive proteins are beneficial to infant health. Recent evidence suggests that maternal nutrition may affect the amount of HMOs and proteins in breast milk; however, the effect of nutrient supplementation on HMOs and bioactive proteins has not yet been well studied. Objective: We aimed to determine whether lipid-based nutrient supplements (LNSs) affect milk bioactive protein and HMO concentrations at 6 mo postpartum in women in rural Malawi. These are secondary outcomes of a previously published randomized controlled trial. Methods: Women were randomly assigned to consume either an iron and folic acid capsule (IFA) daily from #20 wk gestation until delivery, followed by placebo daily from delivery to 6 mo postpartum, or amultiplemicronutrient (MMN) capsule or LNS daily from ?20 wk gestation to 6 mo postpartum. Breast milk concentrations of total HMOs, sialylated HMOs, fucosylated HMOs, lactoferrin, lactalbumin, lysozymes, antitrypsin, immunoglobulin A, and osteopontin were analyzed at 6 mo postpartum (n = 647). Between-group differences in concentrations and in proportions of women classified as having low concentrations were tested. Results: HMO and bioactive protein concentrations did not differ between groups (P > 0.10 for all comparisons). At 6 mo postpartum, the proportions of women with low HMOs or bioactive proteins were not different between groups except for osteopontin. A lower proportion of women in the IFA group had low osteopontin compared with the LNS group after adjusting for covariates (OR: 0.5; 95% CI: 0.3, 0.9; P = 0.016). Conclusion: The study findings do not support the hypothesis that supplementation with an LNS or MMN capsule during pregnancy and postpartum would increase HMO or bioactive milk proteins at 6 mo postpartum among Malawian women. This trial was registered at clinicaltrials.gov as NCT01239693. © 2017 American Society for Nutrition. | |
dc.publisher | American Society for Nutrition | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | bioactive protein | |
dc.subject | folic acid | |
dc.subject | immunoglobulin A | |
dc.subject | iron | |
dc.subject | lactalbumin | |
dc.subject | lactoferrin | |
dc.subject | lysozyme | |
dc.subject | milk protein | |
dc.subject | oligosaccharide | |
dc.subject | osteopontin | |
dc.subject | placebo | |
dc.subject | trace element | |
dc.subject | trypsin inhibitor | |
dc.subject | unclassified drug | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | breast milk | |
dc.subject | concentration (parameters) | |
dc.subject | controlled study | |
dc.subject | diet supplementation | |
dc.subject | drug capsule | |
dc.subject | female | |
dc.subject | fucosylation | |
dc.subject | gestational age | |
dc.subject | human | |
dc.subject | lactation | |
dc.subject | lipid based nutrient supplement | |
dc.subject | major clinical study | |
dc.subject | Malawi | |
dc.subject | maternal age | |
dc.subject | maternal nutrition | |
dc.subject | nutritional status | |
dc.subject | obstetric delivery | |
dc.subject | outcome assessment | |
dc.subject | parity | |
dc.subject | pregnancy | |
dc.subject | pregnant woman | |
dc.subject | protein analysis | |
dc.subject | protein quality | |
dc.subject | puerperium | |
dc.subject | randomized controlled trial | |
dc.subject | secondary analysis | |
dc.subject | sialylation | |
dc.subject | social status | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.3945/jn.117.252981 | |
dc.description.sourcetitle | Journal of Nutrition | |
dc.description.volume | 147 | |
dc.description.issue | 10 | |
dc.description.page | 1867-1874 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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