Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep26097
Title: Early clearance of Chikungunya virus in children is associated with a strong innate immune response
Authors: Simarmata, D
Ng, D.C.E
Kam, Y.-W
Lee, B
Sum, M.S.H
Her, Z
Chow, A 
Leo, Y.-S 
Cardosa, J
Perera, D
Ooi, M.H
Ng, L.F.P 
Keywords: autacoid
cytokine
signal peptide
adult
chikungunya
Chikungunya virus
child
cohort analysis
female
human
immunology
infant
innate immunity
Malaysia
male
meta analysis
metabolism
physiology
preschool child
viremia
virus load
Adult
Chikungunya Fever
Chikungunya virus
Child
Child, Preschool
Cohort Studies
Cytokines
Female
Humans
Immunity, Innate
Infant
Inflammation Mediators
Intercellular Signaling Peptides and Proteins
Malaysia
Male
Viral Load
Viremia
Issue Date: 2016
Citation: Simarmata, D, Ng, D.C.E, Kam, Y.-W, Lee, B, Sum, M.S.H, Her, Z, Chow, A, Leo, Y.-S, Cardosa, J, Perera, D, Ooi, M.H, Ng, L.F.P (2016). Early clearance of Chikungunya virus in children is associated with a strong innate immune response. Scientific Reports 6 : 26097. ScholarBank@NUS Repository. https://doi.org/10.1038/srep26097
Rights: Attribution 4.0 International
Abstract: Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178910
ISSN: 20452322
DOI: 10.1038/srep26097
Rights: Attribution 4.0 International
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