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Title: Sumalactones A-D, four new curvularin-type macrolides from a marine deep sea fungus: Penicillium Sumatrense
Authors: Wu, Y.-H
Zhang, Z.-H
Zhong, Y
Huang, J.-J
Li, X.-X
Jiang, J.-Y
Deng, Y.-Y
Zhang, L.-H 
He, F
Keywords: Metabolites
Nitric oxide
Spectroscopic analysis
Absolute configuration
CD spectra
Deep sea sediment
IC50 value
Inhibition activity
Marine fungus
Mosher's method
Raw 264.7 macrophages
Drug products
Issue Date: 2017
Citation: Wu, Y.-H, Zhang, Z.-H, Zhong, Y, Huang, J.-J, Li, X.-X, Jiang, J.-Y, Deng, Y.-Y, Zhang, L.-H, He, F (2017). Sumalactones A-D, four new curvularin-type macrolides from a marine deep sea fungus: Penicillium Sumatrense. RSC Advances 7 (63) : 40015-40019. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Sumalactones A-D (1-4), four new curvularin-type macrolides, together with two known analogues, curvularin (5) and dehydrocurvularin (6), were isolated from Penicillium Sumatrense, a marine fungus isolated from deep-sea sediments. Sumalactones C (3) and D (4) are unprecedented curvularin-type macrolides bearing a rare 11-membered macrolide skeleton. Their structures were elucidated on the basis of intensive spectroscopic analysis. The absolute configurations of compounds 1-4 were determined by CD spectra and modified Mosher's method. Compound 6 showed significant inhibition activity towards LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 0.91 ?M. © 2017 The Royal Society of Chemistry.
Source Title: RSC Advances
ISSN: 20462069
DOI: 10.1039/c7ra06933b
Rights: Attribution 4.0 International
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