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https://doi.org/10.1038/srep40671
Title: | Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study | Authors: | Leung, Y.-Y Allen, J.C Ang, L.-W Yuan, J.-M Koh, W.-P |
Keywords: | aged body mass diabetes mellitus diabetic complication ethnic group ethnology female follow up health survey human knee osteoarthritis knee replacement male middle aged proportional hazards model prospective study risk factor Singapore statistics and numerical data Aged Arthroplasty, Replacement, Knee Body Mass Index Diabetes Complications Diabetes Mellitus Ethnic Groups Female Follow-Up Studies Humans Male Middle Aged Osteoarthritis, Knee Proportional Hazards Models Prospective Studies Public Health Surveillance Risk Factors Singapore |
Issue Date: | 2017 | Citation: | Leung, Y.-Y, Allen, J.C, Ang, L.-W, Yuan, J.-M, Koh, W.-P (2017). Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study. Scientific Reports 7 : 40671. ScholarBank@NUS Repository. https://doi.org/10.1038/srep40671 | Rights: | Attribution 4.0 International | Abstract: | Association between diabetes mellitus (diabetes) and risk of knee osteoarthritis (KOA) is confounded by high body mass index (BMI), a strong risk factor for both conditions. We evaluated the association between diabetes and incidence of total knee replacement (TKR) due to severe KOA in the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese men and women, aged 45-74 years at recruitment in 1993-1998, and re-interviewed in 1999-2004. Height, weight, lifestyle factors and history of diabetes were obtained through in-person interviews at recruitment and re-interview. Incident cases of TKR were identified via record linkage with nationwide hospital discharge database. Subjects with/without prevalent diabetes had comparable BMI (24.0 kg/m 2 versus 23.0 kg/m 2). After an average of 14-years, 1,973 subjects had TKR attributable to KOA. Compared to subjects without diabetes, hazard ratio (HR) of TKR for subjects with diabetes was 0.63 [95% confidence interval (CI), 0.52-0.75] after controlling for BMI and other risk factors. An inverse association was also observed between incident diabetes at re-interview and subsequent risk of TKR (HR = 0.74; 95% CI = 0.58-0.94). The inverse diabetes-TKR risk association was similar by gender and across three categories of BMI. Our study does not support diabetes as a risk factor of KOA. © The Author(s) 2017. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/178709 | ISSN: | 20452322 | DOI: | 10.1038/srep40671 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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