Please use this identifier to cite or link to this item: https://doi.org/10.14814/phy2.13248
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dc.titleResting heart rate variability and exercise capacity in Type 1 diabetes
dc.contributor.authorWilson, L.C
dc.contributor.authorPeebles, K.C
dc.contributor.authorHoye, N.A
dc.contributor.authorManning, P
dc.contributor.authorSheat, C
dc.contributor.authorWilliams, M.J.A
dc.contributor.authorWilkins, G.T
dc.contributor.authorWilson, G.A
dc.contributor.authorBaldi, J.C
dc.date.accessioned2020-10-21T07:54:31Z
dc.date.available2020-10-21T07:54:31Z
dc.date.issued2017
dc.identifier.citationWilson, L.C, Peebles, K.C, Hoye, N.A, Manning, P, Sheat, C, Williams, M.J.A, Wilkins, G.T, Wilson, G.A, Baldi, J.C (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports 5 (8) : e13248. ScholarBank@NUS Repository. https://doi.org/10.14814/phy2.13248
dc.identifier.issn2051817X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178683
dc.description.abstractPeople with type 1 diabetes (T1D) have lower exercise capacity (V?O2max) than their age-matched nondiabetic counterparts (CON), which might be related to cardiac autonomic dysfunction. We examined whether Heart Rate Variability (HRV; indicator of cardiac autonomic modulation) was associated with exercise capacity in those with and without T1D. Twenty-three participants with uncomplicated T1D and 17 matched CON were recruited. Heart rate (HR; ECG), blood pressure (BP; finger photo-plethysmography), and respiratory rate (respiratory belt) were measured during baseline, paced-breathing and clinical autonomic reflex tests (CARTs); deep breathing, lying-to-stand, and Valsalva maneuver. Baseline and paced-breathing ECG were analyzed for HRV (frequency-domain). Exercise capacity was determined during an incremental cycle ergometer test while V?O2, 12-lead ECG, and BP were measured. In uncomplicated T1D, resting HR was elevated and resting HRV metrics were reduced, indicative of altered cardiac parasympathetic modulation; this was generally undetected by the CARTs. However, BP and plasma catecholamines were not different between groups. In T1D, V?O2max tended to be lower (P = 0.07) and HR reserve was lower (P < 0.01). Resting Total Power (TP) had stronger positive associations with V?O2max (R2 ? 0.3) than all other traditional indicators such as age, resting HR, and self-reported exercise (R2= 0.042–0.3) in both T1D and CON. Alterations in cardiac autonomic modulation are an early manifestation of uncomplicated T1D. Total Power was associated with reduced exercise capacity regardless of group, and these associations were generally stronger than traditional indicators. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjecthemoglobin A1c
dc.subjectcatecholamine
dc.subjectadolescent
dc.subjectadrenalin blood level
dc.subjectadult
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectbicycle ergometry
dc.subjectblood glucose monitoring
dc.subjectblood pressure
dc.subjectbody mass
dc.subjectbreathing rate
dc.subjectcatecholamine blood level
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectelectrocardiography
dc.subjectelectrochemical detection
dc.subjectexercise
dc.subjectfemale
dc.subjectheart rate
dc.subjectheart rate variability
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjectinsulin dependent diabetes mellitus
dc.subjectinsulin treatment
dc.subjectmale
dc.subjectnoradrenalin blood level
dc.subjectphysical activity
dc.subjectquestionnaire
dc.subjectresting heart rate
dc.subjectblood
dc.subjectbreathing
dc.subjectcase control study
dc.subjectheart rate
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectoxygen consumption
dc.subjectpathophysiology
dc.subjectAdult
dc.subjectBlood Pressure
dc.subjectCase-Control Studies
dc.subjectCatecholamines
dc.subjectDiabetes Mellitus, Type 2
dc.subjectExercise
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectOxygen Consumption
dc.subjectRespiration
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.14814/phy2.13248
dc.description.sourcetitlePhysiological Reports
dc.description.volume5
dc.description.issue8
dc.description.pagee13248
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