Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep45901
Title: A randomized controlled trial of an ambulatory approach versus the hospital-based approach in managing suspected obstructive sleep apnea syndrome
Authors: Hui, D.S
Ng, S.S
To, K.-W
Ko, F.W
Ngai, J
Chan, K.K.P
Yip, W.-H
Chan, T.-O
Yiu, K
Tam, W.W.S 
Keywords: adult
aged
ambulatory care
controlled study
economics
female
health economics
human
male
middle aged
polysomnography
positive end expiratory pressure
procedures
randomized controlled trial
sleep disordered breathing
very elderly
Adult
Aged
Aged, 80 and over
Ambulatory Care
Continuous Positive Airway Pressure
Economics, Hospital
Female
Humans
Male
Middle Aged
Polysomnography
Sleep Apnea, Obstructive
Issue Date: 2017
Citation: Hui, D.S, Ng, S.S, To, K.-W, Ko, F.W, Ngai, J, Chan, K.K.P, Yip, W.-H, Chan, T.-O, Yiu, K, Tam, W.W.S (2017). A randomized controlled trial of an ambulatory approach versus the hospital-based approach in managing suspected obstructive sleep apnea syndrome. Scientific Reports 8 : 45901. ScholarBank@NUS Repository. https://doi.org/10.1038/srep45901
Rights: Attribution 4.0 International
Abstract: Comparisons of home-based versus hospital-based approach in managing patients with suspected obstructive sleep apnoea syndrome(OSAS). A prospective, controlled CPAP parallel study of new referrals with suspected OSAS randomized into group A) home-based or B) hospital-based approach. Following detection of AHI ? 15/hr by Embletta sleep study (group A) or polysomnography (group B), patients received CPAP for 3 months after an overnight autoCPAP titration at home or in hospital respectively. Modified intention-To-Treat analysis of those with AHI ? 15/hr on CPAP (n = 86 vs 86) showed no difference in Epworth sleepiness score, the primary endpoint, but greater improvement in Sleep-Apnoea-Quality-of-Life-Index[difference 0.3,(95%CI 0.02, 0.6), p = 0.033] at 3 months in group A. The mean costs for the patients in group A and group B were HK8479(989) and HK22,248(2407) respectively. The mean difference between groups was HK-13,769(USD 1770 equivalent) per patient with 95% CI. (â'14324, â'13213), p < 0.001. The waiting time of patients with AHI ? 15/hr who were started on CPAP treatment from the first clinic consultation to the diagnostic sleep test, autoCPAP titration, and CPAP treatment was 189.6, 148.8 and 145.0 days shorter in group A than group B respectively. Home-based approach is non-inferior to hospital-based approach in managing patients with suspected OSAS, with shorter waiting time, and substantial cost savings. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178681
ISSN: 20452322
DOI: 10.1038/srep45901
Rights: Attribution 4.0 International
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