Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-11166-4
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dc.title5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore
dc.contributor.authorKenyon, J.J
dc.contributor.authorNotaro, A
dc.contributor.authorHsu, L.Y
dc.contributor.authorDe Castro, C
dc.contributor.authorHall, R.M
dc.date.accessioned2020-10-20T10:24:15Z
dc.date.available2020-10-20T10:24:15Z
dc.date.issued2017
dc.identifier.citationKenyon, J.J, Notaro, A, Hsu, L.Y, De Castro, C, Hall, R.M (2017). 5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore. Scientific Reports 7 (1) : 11357. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-11166-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178579
dc.description.abstractNonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isolate was determined. The isolate carries a sugar synthesis module that differs by only a single gene from the module for the synthesis of 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-altro-non-2-ulosonic acid or 5,7-di-N-acetylacinetaminic acid, recently discovered in the capsule of another A. baumannii isolate. The new monosaccharide is the C8-epimer of acinetaminic acid (8eAci; 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-L-altro-non-2-ulosonic acid) and the C7-epimer of legionaminic acid. This monosaccharide had not previously been detected in a biological sample but had been synthesized chemically. © 2017 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbacterial polysaccharide
dc.subjectsugar acid
dc.subjectAcinetobacter baumannii
dc.subjectbacterial capsule
dc.subjectbacterial gene
dc.subjectbiology
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectgenetics
dc.subjecthydrolysis
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectmultigene family
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectprocedures
dc.subjectSingapore
dc.subjectAcinetobacter baumannii
dc.subjectBacterial Capsules
dc.subjectComputational Biology
dc.subjectGenes, Bacterial
dc.subjectHydrolysis
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMolecular Structure
dc.subjectMultigene Family
dc.subjectPolysaccharides, Bacterial
dc.subjectSingapore
dc.subjectSugar Acids
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1038/s41598-017-11166-4
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page11357
dc.published.statepublished
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