Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-11166-4
Title: 5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore
Authors: Kenyon, J.J
Notaro, A
Hsu, L.Y 
De Castro, C
Hall, R.M
Keywords: bacterial polysaccharide
sugar acid
Acinetobacter baumannii
bacterial capsule
bacterial gene
biology
chemical structure
chemistry
genetics
hydrolysis
isolation and purification
metabolism
multigene family
nuclear magnetic resonance spectroscopy
procedures
Singapore
Acinetobacter baumannii
Bacterial Capsules
Computational Biology
Genes, Bacterial
Hydrolysis
Magnetic Resonance Spectroscopy
Molecular Structure
Multigene Family
Polysaccharides, Bacterial
Singapore
Sugar Acids
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Kenyon, J.J, Notaro, A, Hsu, L.Y, De Castro, C, Hall, R.M (2017). 5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore. Scientific Reports 7 (1) : 11357. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-11166-4
Rights: Attribution 4.0 International
Abstract: Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isolate was determined. The isolate carries a sugar synthesis module that differs by only a single gene from the module for the synthesis of 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-altro-non-2-ulosonic acid or 5,7-di-N-acetylacinetaminic acid, recently discovered in the capsule of another A. baumannii isolate. The new monosaccharide is the C8-epimer of acinetaminic acid (8eAci; 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-L-altro-non-2-ulosonic acid) and the C7-epimer of legionaminic acid. This monosaccharide had not previously been detected in a biological sample but had been synthesized chemically. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178579
ISSN: 2045-2322
DOI: 10.1038/s41598-017-11166-4
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41598-017-11166-4.pdf1.63 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

19
checked on Nov 27, 2020

Page view(s)

10
checked on Nov 26, 2020

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons