Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-017-00377-y
Title: Mitochondrial mutations drive prostate cancer aggression
Authors: Hopkins, J.F
Sabelnykova, V.Y
Weischenfeldt, J
Simon, R
Aguiar, J.A
Alkallas, R
Heisler, L.E
Zhang, J
Watson, J.D
Chua, M.L.K 
Fraser, M
Favero, F
Lawerenz, C
Plass, C
Sauter, G
McPherson, J.D
Van Der Kwast, T
Korbel, J
Schlomm, T
Bristow, R.G
Boutros, P.C
Keywords: mitochondrial DNA
mitochondrial DNA
cancer
disease incidence
genome
mitochondrion
tumor
adult
age
androgen deprivation therapy
Article
cancer growth
cancer localization
cancer radiotherapy
cancer survival
cohort analysis
controlled study
gene control
gene dosage
gene interaction
gene locus
gene sequence
Gleason score
human
human tissue
major clinical study
male
mitochondrial gene
mitochondrial genome
mitochondrion
oncogene myc
prostate cancer
prostatectomy
single nucleotide polymorphism
somatic mutation
adenocarcinoma
aged
genetic association study
genetics
middle aged
pathology
point mutation
prostate tumor
survival analysis
tumor invasion
very elderly
Adenocarcinoma
Adult
Age Factors
Aged
Aged, 80 and over
DNA, Mitochondrial
Genes, myc
Genetic Association Studies
Genome, Mitochondrial
Humans
Male
Middle Aged
Neoplasm Invasiveness
Point Mutation
Prostatic Neoplasms
Survival Analysis
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Hopkins, J.F, Sabelnykova, V.Y, Weischenfeldt, J, Simon, R, Aguiar, J.A, Alkallas, R, Heisler, L.E, Zhang, J, Watson, J.D, Chua, M.L.K, Fraser, M, Favero, F, Lawerenz, C, Plass, C, Sauter, G, McPherson, J.D, Van Der Kwast, T, Korbel, J, Schlomm, T, Bristow, R.G, Boutros, P.C (2017). Mitochondrial mutations drive prostate cancer aggression. Nature Communications 8 (1) : 656. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00377-y
Rights: Attribution 4.0 International
Abstract: Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer. © 2017 The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/178575
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00377-y
Rights: Attribution 4.0 International
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