Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-16464-5
Title: Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China
Authors: Huang, Y 
Wu, Y
Yang, Y
Li, W
Lu, J
Hu, Y
Keywords: 1 alkyl 2 acetylglycerophosphocholine esterase
biological marker
C reactive protein
cholesterol
low density lipoprotein
oxidized low density lipoprotein
triacylglycerol
acute coronary syndrome
adult
blood
female
human
male
metabolism
middle aged
multivariate analysis
risk factor
statistical model
1-Alkyl-2-acetylglycerophosphocholine Esterase
Acute Coronary Syndrome
Adult
Biomarkers
C-Reactive Protein
Cholesterol
Female
Humans
Lipoproteins, LDL
Logistic Models
Male
Middle Aged
Multivariate Analysis
Risk Factors
Triglycerides
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Huang, Y, Wu, Y, Yang, Y, Li, W, Lu, J, Hu, Y (2017). Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China. Scientific Reports 7 (1) : 16092. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-16464-5
Rights: Attribution 4.0 International
Abstract: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered to be a risk factor for acute coronary syndrome (ACS), but this remains controversial. This study investigated the role of Lp-PLA2 in young Chinese patients with ACS. 228 young patients (aged ?55 years) with ACS and 237 age-matched controls were included. Lp-PLA2 and oxidized low-density lipoprotein (ox-LDL) levels were measured by sandwich enzyme-linked immunosorbent assay. Lp-PLA2 levels were significantly correlated with smoking, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and ox-LDL levels (all P < 0.05). Multivariate logistic regression analysis showed that male sex (OR = 3.25, 95%CI = 1.26-8.38), smoking (OR = 3.50, 95%CI = 1.75-7.0), triglyceride (OR = 1.76, 95%CI = 1.08-2.87), high sensitivity C-reactive protein (hs-CRP) (OR = 2.11, 95%CI = 1.14-3.90) and ox-LDL (OR = 2.98, 95%CI = 1.72-5.1) were independently associated with ACS risk in young patients. Lp-PLA2 was associated with risk of ACS in young patients when adjusted for traditional risk factors, including age, sex, diabetes, hypertension, smoking, TC, LDL-C, triglyceride and hs-CRP (OR = 1.98, 95%CI = 1.10-3.56). When further adjusted for ox-LDL levels, the association between Lp-PLA2 and ACS became insignificant (OR = 1.69, 95%CI = 0.90-3.17). Lp-PLA2 was a marker of oxidative stress and inflammation, rather than an independent risk factor for ACS in young Chinese patients. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178558
ISSN: 2045-2322
DOI: 10.1038/s41598-017-16464-5
Rights: Attribution 4.0 International
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