Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-20267-7
Title: Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE)
Authors: Liu, Y.-C 
Teo, E.P.W
Ang, H.P
Seah, X.Y
Lwin, N.C
Yam, G.H.F 
Mehta, J.S 
Keywords: allotransplantation
animal
cornea
cornea stroma
cornea transplantation
Macaca fascicularis
optical coherence tomography
physiology
presbyopia
procedures
visual acuity
Animals
Cornea
Corneal Stroma
Corneal Transplantation
Macaca fascicularis
Presbyopia
Tomography, Optical Coherence
Transplantation, Homologous
Visual Acuity
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Liu, Y.-C, Teo, E.P.W, Ang, H.P, Seah, X.Y, Lwin, N.C, Yam, G.H.F, Mehta, J.S (2018). Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). Scientific Reports 8 (1) : 1831. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-20267-7
Rights: Attribution 4.0 International
Abstract: Corneal inlays are a relatively new treatment option for presbyopia. Using biological inlays, derived from lenticules extracted from small incision lenticule extraction, may offer advantages over commercialized synthetic inlays in the aspect of biocompatibility. We conducted a non-human primate study to evaluate the safety, predictability, efficacy and tissue response after autogeneic, decellularized xenogeneic and xenogeneic lenticule implantation. The lenticule implantation effectively resulted in central corneal steepening (simulated keratometric values increased by 1.8-2.3 diopters), central hyper-prolate changes (asphericity Q values changed by -0.26 to -0.36), corneal anterior surface elevation (7.7-9.3 ?m) and reasonable effective zone (1.5-1.8 times of the lenticule physical diameter), with no differences among the three groups. Slit lamp microscopy, transmission electron microscopy, confocal microscopy, histology and immunohistochemistry analyses confirmed the biocompatibility of the autogeneic and decellularized lenticules, whereas one eye in the xenogeneic group developed corneal stromal rejection during the study period. Our results showed that lenticule implantation has the potential for the management of presbyopia, and provide the basis for future clinical studies. The decellularization process may increase the potential utilization of lenticules without changing the efficacy. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178459
ISSN: 2045-2322
DOI: 10.1038/s41598-018-20267-7
Rights: Attribution 4.0 International
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