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https://doi.org/10.1038/s41467-018-06981-w
Title: | Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery | Authors: | Than, A Liu, C Chang, H Duong, P.K Cheung, C.M.G Xu, C Wang, X Chen, P |
Keywords: | diclofenac eye drops hyaluronic acid immunoglobulin G interleukin 6 monoclonal antibody DC101 vasculotropin inhibitor drug vasculotropin A antibody array drug eye disease injury reaction kinetics animal experiment animal model antiangiogenic activity Article confocal microscopy controlled study cornea disease cornea neovascularization drug delivery system drug megadose drug potentiation drug safety drug solubility ex vivo study human human tissue male microtechnology molecular weight mouse nonhuman pig polyacrylamide gel electrophoresis proof of concept scanning electron microscopy sustained drug release topical treatment treatment outcome animal antagonists and inhibitors delayed release formulation drug effect eye inflammation metabolism needle pathology prostheses and orthoses Animals Delayed-Action Preparations Drug Delivery Systems Eye Inflammation Mice Needles Pharmaceutical Preparations Prostheses and Implants Sus scrofa Vascular Endothelial Growth Factor A |
Issue Date: | 2018 | Publisher: | Nature Publishing Group | Citation: | Than, A, Liu, C, Chang, H, Duong, P.K, Cheung, C.M.G, Xu, C, Wang, X, Chen, P (2018). Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications 9 (1) : 4433. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-06981-w | Rights: | Attribution 4.0 International | Abstract: | Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can penetrate the ocular surface tissue, and serve as implanted micro-reservoirs for controlled drug delivery. The biphasic drug release kinetics enabled by the double-layered micro-reservoirs largely enhances therapeutic efficacy. Using corneal neovascularization as the disease model, we show that delivery of an anti-angiogenic monoclonal antibody (DC101) by such eye patch produces ~90% reduction of neovascular area. Furthermore, quick release of an anti-inflammatory compound (diclofenac) followed by a sustained release of DC101 provides synergistic therapeutic outcome. The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases. © 2018, The Author(s). | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/178384 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-018-06981-w | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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