Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-07400-8
DC FieldValue
dc.titleDefining a critical period for inhibitory circuits within the somatosensory cortex
dc.contributor.authorLo, S.Q
dc.contributor.authorSng, J.C.G
dc.contributor.authorAugustine, G.J
dc.date.accessioned2020-10-20T09:09:21Z
dc.date.available2020-10-20T09:09:21Z
dc.date.issued2017
dc.identifier.citationLo, S.Q, Sng, J.C.G, Augustine, G.J (2017). Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports 7 (1) : 7271. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-07400-8
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178309
dc.description.abstractAlthough experience-dependent changes in brain inhibitory circuits are thought to play a key role during the "critical period" of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit. © 2017 The Author(s).
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbiological marker
dc.subjectparvalbumin
dc.subjectanimal
dc.subjectelectrophysiology
dc.subjectinterneuron
dc.subjectmetabolism
dc.subjectmouse
dc.subjectnerve cell plasticity
dc.subjectoptogenetics
dc.subjectpatch clamp technique
dc.subjectphysiology
dc.subjectpyramidal nerve cell
dc.subjectreporter gene
dc.subjectsomatosensory cortex
dc.subjecttransgenic mouse
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectElectrophysiological Phenomena
dc.subjectGenes, Reporter
dc.subjectInterneurons
dc.subjectMice
dc.subjectMice, Transgenic
dc.subjectNeuronal Plasticity
dc.subjectOptogenetics
dc.subjectParvalbumins
dc.subjectPatch-Clamp Techniques
dc.subjectPyramidal Cells
dc.subjectSomatosensory Cortex
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-017-07400-8
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page7271
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41598-017-07400-8.pdf4.13 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons