Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-07400-8
Title: Defining a critical period for inhibitory circuits within the somatosensory cortex
Authors: Lo, S.Q 
Sng, J.C.G 
Augustine, G.J 
Keywords: biological marker
parvalbumin
animal
electrophysiology
interneuron
metabolism
mouse
nerve cell plasticity
optogenetics
patch clamp technique
physiology
pyramidal nerve cell
reporter gene
somatosensory cortex
transgenic mouse
Animals
Biomarkers
Electrophysiological Phenomena
Genes, Reporter
Interneurons
Mice
Mice, Transgenic
Neuronal Plasticity
Optogenetics
Parvalbumins
Patch-Clamp Techniques
Pyramidal Cells
Somatosensory Cortex
Issue Date: 2017
Citation: Lo, S.Q, Sng, J.C.G, Augustine, G.J (2017). Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports 7 (1) : 7271. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-07400-8
Rights: Attribution 4.0 International
Abstract: Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the "critical period" of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178309
ISSN: 20452322
DOI: 10.1038/s41598-017-07400-8
Rights: Attribution 4.0 International
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