Please use this identifier to cite or link to this item:
Title: Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma
Authors: Chen, L 
Chan, T.H.M 
Guan, X.-Y
Keywords: caspase 3
caspase 9
cyclic AMP dependent protein kinase regulatory subunit Ibeta
cyclic AMP responsive element binding protein
binding affinity
cancer growth
cancer therapy
cell cycle progression
cell cycle regulation
cell proliferation
chromosome 13q
chromosome 16p
chromosome 17p
chromosome 17q
chromosome 1q
chromosome 20q
chromosome 4q
chromosome 6q
chromosome 8p
chromosome aberration
comparative genomic hybridization
copy number variation
distant metastasis
drug inhibition
gene amplification
gene loss
gene overexpression
gene targeting
gene translocation
genetic gain
genetic transfection
liver carcinogenesis
liver cell carcinoma
minimal amplified region
real time polymerase chain reaction
single nucleotide polymorphism
Carcinoma, Hepatocellular
Chromosomes, Human, Pair 1
DNA Helicases
DNA-Binding Proteins
Gene Amplification
Issue Date: 2010
Publisher: Wiley
Citation: Chen, L, Chan, T.H.M, Guan, X.-Y (2010). Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma. Acta Pharmacologica Sinica 31 (9) : 1165-1171. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Hepatocellular carcinoma (HCC) is among the most lethal of human malignancies. During human multistep hepatocarcinogenesis, genomic gain represents an important mechanism in the activation of proto-oncogenes. In many circumstances, activated oncogenes hold clinical implications both as prognostic markers and targets for cancer therapeutics. Gain of chromosome 1q copy is one of the most frequently detected alterations in HCC and 1q21 is the most frequent minimal amplifying region (MAR). A better understanding of the physiological and pathophysiological roles of target genes within 1q21 amplicon will significantly improve our knowledge in HCC pathogenesis, and may lead to a much more effective management of HCC bearing amplification of 1q21. Such knowledge has long term implications for the development of new therapeutic strategies for HCC treatment. Our research group and others, focused on the identification and characterization of 1q21 target genes such as JTB, CKS1B, and CHD1L in HCC progression. In this review, we will summarize the current scientific knowledge of known target genes within 1q21 amplicon and the precise oncogenic mechanisms of CHD1L will be discussed in detail. © 2010 CPS and SIMM All rights reserved.
Source Title: Acta Pharmacologica Sinica
ISSN: 1671-4083
DOI: 10.1038/aps.2010.94
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_aps_2010_94.pdf1.18 MBAdobe PDF



Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons